Publications related to Epistasis

A Quantitative Test of Hamilton's Rule for the Evolution of Altruism

Dario Floreano, Laurent Keller, Markus Waibel

The evolution of altruism is a fundamental and enduring puzzle in biology. In a seminal paper Hamilton showed that altruism can be selected for when rb − c>0, where c is the fitness cost to the altruist, b is the fitness benefit to the beneficiary, and r i ...

Public Library of Science2011

Acute Hypoglycemia Induces Retinal Cell Death in Mouse

Martine Emery

Background: Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Glycemic excursions could lead to cardiovascular disease, nephropathy, neuropathy and retinopathy. ...

Public Library of Science2011

The shine-through masking paradigm is a potential endophenotype of schizophrenia

Michael Herzog, Maya Roinishvili

Background: To understand the genetics of schizophrenia, a hunt for so-called intermediate phenotypes or endophenotypes is ongoing. Visual masking has been proposed to be such an endophenotype. However, no systematic study has been conducted yet to prove t ...

Public Library of Science2010

Gestalt determines contextual modulation

Michael Herzog, Bilge Sayim, Mauro Manassi

Performance deteriorates when a target is flanked by contextual elements. For example, vernier thresholds increase when the vernier is flanked by lines. But when the lines are made part of a “good Gestalt”, like a rectangle, deterioration is reduced. Our e ...

2010

Nominal and ordinal predictors in logistic regression for the identification of adaptive loci in animal and plant populations

Stéphane Joost, Michaël Kalbermatten

When searching for loci possibly under selection in the genome, an alternative to population genetics theoretical models is to establish allele distribution models for each locus to directly correlate allelic frequencies and environmental variables like pr ...

2010

Systematic Inference of Copy-Number Genotypes from Personal Genome Sequencing Data Reveals Extensive Olfactory Receptor Gene Content Diversity

Sebastian Martin Waszak

Copy-number variations (CNVs) are widespread in the human genome, but comprehensive assignments of integer locus copy-numbers (i.e., copy-number genotypes) that, for example, enable discrimination of homozygous from heterozygous CNVs, have remained challen ...

Public Library of Science2010

Ion irradiation enhances the mechanical performance of metallic glasses

Johann Michler, Manuel Alexandre Pouchon

We demonstrate that irradiation may enhance the plasticity in metallic glasses by increasing the free-volume content via micropillar compression experiments on an ion-irradiated bulk metallic glass (BMG). Results show that irradiation decreases the flow st ...

Elsevier2010

Common genetic variation and the control of HIV-1 in humans

Jacques Fellay, Patrick Descombes, Amalio Telenti

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the ...

2009

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Epistasis

A Quantitative Test of Hamilton's Rule for the Evolution of Altruism

Acute Hypoglycemia Induces Retinal Cell Death in Mouse

The shine-through masking paradigm is a potential endophenotype of schizophrenia

Gestalt determines contextual modulation

Nominal and ordinal predictors in logistic regression for the identification of adaptive loci in animal and plant populations

Systematic Inference of Copy-Number Genotypes from Personal Genome Sequencing Data Reveals Extensive Olfactory Receptor Gene Content Diversity

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

Ion irradiation enhances the mechanical performance of metallic glasses

Common genetic variation and the control of HIV-1 in humans

Evolution of stochastic switching rates in asymmetric fitness landscapes

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Chat with Graph Search

Acute Hypoglycemia Induces Retinal Cell Death in Mouse

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

Common genetic variation and the control of HIV-1 in humans

Evolution of stochastic switching rates in asymmetric fitness landscapes

Ion irradiation enhances the mechanical performance of metallic glasses

Nominal and ordinal predictors in logistic regression for the identification of adaptive loci in animal and plant populations

Gestalt determines contextual modulation

A Quantitative Test of Hamilton's Rule for the Evolution of Altruism

The shine-through masking paradigm is a potential endophenotype of schizophrenia

Systematic Inference of Copy-Number Genotypes from Personal Genome Sequencing Data Reveals Extensive Olfactory Receptor Gene Content Diversity