Concept

Cell damage

Related publications (109)

Neurotoxicity of manganese oxide nanomaterials

Manganese (Mn) toxicity in humans has been observed as manganism, a disease that resembles Parkinson's disease. The mechanism of Mn toxicity and the chemical forms that may be responsible for its neurotoxicity are not well understood. We examined the toxic ...

2009

Telomerase is essential to alleviate pif1-induced replication stress at telomeres

Joachim Lingner

Pif1, an evolutionarily conserved helicase, negatively regulates telomere length by removing telomerase from chromosome ends. Pif1 has also been implicated in DNA replication processes Such as Okazaki fragment maturation and replication fork pausing. We fi ...

2009

H2AX is required for cell cycle arrest via the p53/p21 pathway

Peter Martin Beard, Michail Fragkos

Phosphorylation of H2AX (gamma H2AX) is an early sign of DNA damage induced by replication stalling. However, the role of H2AX in the repair of this type of DNA damage is still unclear. In this study, we used an inactivated adeno-associated virus (AAV) to ...

2009

Membrane injury by pore-forming proteins

Françoise Gisou van der Goot Grunberg, Mirko Bischofberger, Rodrigo Manuel Gonzalez

The plasma membrane defines the boundary of every living cell, and its integrity is essential for life. The plasma membrane may, however, be challenged by mechanical stress or pore-forming proteins produced by the organism itself or invading pathogens. We ...

Elsevier2009

MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells

The retinal pigment epithelium (RPE) is constantly exposed to external injuries which lead to degeneration, dysfunction or loss of RPE cells. The balance between RPE cells death and proliferation may be responsible for several diseases of the underlying re ...

2008

Bacterial pore-forming toxins: the (w)hole story?

Françoise Gisou van der Goot Grunberg, Rodrigo Manuel Gonzalez

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response t ...

Birkhäuser-Verlag, Springer2008

Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling

Peter Martin Beard, Michail Fragkos

Adeno-associated virus (AAV) DNA, by mimicking a stalled replication fork, provokes a DNA damage response that can arrest cells in the G2/M phase of the cell-cycle. This response depends strictly on DNA damage signaling kinases ATR and Chk1. Here, we used ...

2007

Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6

Peter Martin Beard

Adeno-associated virus (AAV) infection triggers a DNA damage response in the cell. This response is not induced by viral proteins but by virtue of the structure of AAV ssDNA being recognized by the cell as damaged DNA. The consequence of this is the killin ...

2007

Label-free detection of Babesia bovis infected red blood cells using impedance spectroscopy on microfabricated flow cytometer

Philippe Renaud, Thomas Michael Braschler, Nicolas Demierre

Impedance spectroscopy is a powerful tool for label-free analysis and characterisation of living cells. In this work, we achieved the detection of Babesia bovis infected red blood cells using impedance spectroscopy on a microfabricated flow cytometer. The ...

2007

Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Laure Gurcel

Many pathogenic organisms produce pore-forming toxins as virulence factors. Target cells however mount a response to such membrane damage. Here we show that toxin-induced membrane permeabilization leads to a decrease in cytoplasmic potassium, which promote ...

2006

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