Concept

Cysteine

Related publications (80)

A Biocompatible in Vivo Ligation Reaction and Its Application for Noninvasive Bioluminescent Imaging of Protease Activity in Living Mice

Douglas Hanahan, Aurélien Godinat, Gennady Nikitin, Ke Cheng

The discovery of biocompatible reactions had a tremendous impact on chemical biology, allowing the study of numerous biological processes directly in complex systems. However, despite the fact that multiple biocompatible reactions have been developed in th ...

Amer Chemical Soc2013

Chemical macrocyclization of peptides fused to antibody Fc fragments

Christian Heinis, David Hacker, Laure Menin, Alessandro Angelini, Philippe Diderich, Julia Morales Sanfrutos, Sarah Thurnheer

To extend the plasma half-life of a bicyclic peptide antagonist, we chose to link it to the Fc fragment of the long-lived serum protein IgG1. Instead of chemically conjugating the entire bicyclic peptide, we recombinantly expressed its peptide moiety as a ...

Amer Chemical Soc2012

Voltammetric Detection of Hg2+ Using Peptide-Functionalized Polymer Brushes

Harm-Anton Klok, Maarten Danial

Polymer brushes grafted by surface-initiated atom transfer radical polymerization (SI-ATRP) from the surface of Ir-based microelectrode arrays are explored as a platform for the fabrication of sensory coatings for the voltammetric detection of Hg2+. The po ...

Csiro Publishing2012

Encapsulation of Huh-7 cells within alginate-poly(ethylene glycol) hybrid microspheres

Jutta Christine Wandrey, Redouan Mahou

Novel calcium alginate poly(ethylene glycol) hybrid microspheres (Ca-alg-PEG) were developed and evaluated as potentially suitable materials for cell microencapsulation. Grafting 5-13% of the backbone units of sodium alginate (Na-alg) with alpha-amine-omeg ...

Springer US2012

Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A

Ronan Euzen, Jean-Louis Reymond

We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con A ...

Elsevier2011

Post-translational modification of genetically encoded polypeptide libraries

Christian Heinis, Alessandro Angelini

The genetic encoding of polypeptides with biological display systems enables the facile generation and screening of very large combinatorial libraries of molecules. By post-translationally modifying the encoded polypeptides, chemically and structurally mor ...

Elsevier2011

Ga2O3 photocatalyzed on-line tagging of cysteine to facilitate peptide mass fingerprinting

Hubert Girault, Liang Qiao, Hongyan Bi

beta-Ga2O3 is a wide-band-gap semiconductor having strong oxidation ability under light irradiation. Herein, the steel target plates modified with beta-Ga2O3 nanoparticles have been developed to carry out in-source photo-catalytic oxidative reactions for o ...

2011

Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis

Stewart Cole, Kai Johnsson, Marlon Hinner, Claudia Trefzer, Monica Rengifo Gonzalez

Benzothiazinones (BTZs) form a new class of potent antimycobacterial agents. Although the target of BTZs has been identified as decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1), their detailed mechanism of action remains obscure. Here we demonstrate th ...

American Chemical Society2010

Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT

Paul Joseph Dyson, Angela Casini, Fabio Edafe

A series of organometallic compds. of general formula [(arene)M(PTA)nXm]Y (arene = η6-C10H14, η-C5Me5); (M = Ru(II), Os(II), Rh(III) and Ir(III); X = Cl, mPTA; Y = OTf, PF6) have been screened for their cytotoxicity and ability to inhibit cathepsin B in vi ...

Royal Society of Chemistry2010

The role of copper in cysteine oxidation: study of intra- and inter-molecular reactions in mass spectrometry

Hubert Girault, Michel Prudent

Cysteine-containing peptide oxidation was studied both by using an inert platinum electrode and a sacrificial electrode (copper or zinc) generating metallic ions in electrospray ionization mass spectrometry (ESI-MS). Using peptides containing one, two and ...

Royal Society of Chemistry2009

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