Publications related to Chemical specificity

Functional characterization of a new tetrachloroethene reductive dehalogenase of Sulfurospirillum spp. identified in mixed cultures

Christof Holliger, Julien Maillard, Géraldine Florence Buttet

Recent analysis of a set of reductive dehalogenases revealed that sequence similarity and substrate specificity are not correlated, making functional prediction from sequences difficult (1). To this respect, several enrichment cultures were investigated fo ...

2014

Functional diversity of reductive dehalogenases in a bacterial consortium degrading chloroethenes

Christof Holliger, Julien Maillard, Géraldine Florence Buttet, Sébastien Keller

Chlorinated hydrocarbon pollution threatens nature and human health due to its toxic and carcinogenic potential. Enrichment cultures were investigated for the bioremediation potential of tetrachloroethene (PCE). This process is based on bacterial anaerobic ...

2014

Functionalization of Nanoparticles for Targeted Cancer Imaging and Diagnosis

Solène Marcelle Françoise Marie Passemard

At present time, cancer is the leading cause of death in developed countries. The medical imaging tools currently used in clinics such as radiology, nuclear magnetic resonance imaging, microscopy and endoscopy are not able to reach the sensitivity necessar ...

EPFL2014

Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Michael van der Kooij, Martina Fantin, Céline Fournier

Chronic stress is a risk factor for the development of psychopathologies characterized by cognitive dysfunction and deregulated social behaviours. Emerging evidence suggests a role for cell adhesion molecules, including nectin-3, in the mechanisms that un ...

2014

Phage Selection of Photoswitchable Peptide Ligands

Christian Heinis, Inmaculada Rentero Rebollo, Shiyu Chen, Silvia Bellotto, Hermann A. Wegner

Photoswitchable ligands are powerful tools to control biological processes at high spatial and temporal resolution. Unfortunately, such ligands exist only for a limited number of proteins and their development by rational design is not trivial. We have dev ...

American Chemical Society2014

Comprehensive study of carbon dioxide adsorption in the metal-organic frameworks M-2(dobdc) (M = Mg, Mn, Fe, Co, Ni, Cu, Zn)

Berend Smit, Wendy Lee Queen, Miguel Gonzalez

Analysis of the CO2 adsorption properties of a well-known series of metal-organic frameworks M-2(dobdc) (dobdc(4-) = 2,5-dioxido-1,4-benzenedicarboxylate; M = Mg, Mn, Fe, Co, Ni, Cu, and Zn) is carried out in tandem with in situ structural studies to ident ...

Royal Soc Chemistry2014

Polypeptide inhibitors of urokinase type plasminogen activator

Christian Heinis, Alessandro Angelini

A conjugate which is capable of specific binding to and inhibition of urokinase-type plasminigen activator (UPA) comprising a polypeptide molecule and a scaffold molecule, wherein said polypeptide molecule is attached to said scaffold molecule by at least ...

2013

Computational, Structural, and Kinetic Evidence That Vibrio vulnificus FrsA Is Not a Cofactor-Independent Pyruvate Decarboxylase

Ursula Röthlisberger, Elizabeth Claire Brunk

The fermentation-respiration switch (FrsA) protein in Vibrio vulnificus was recently reported to catalyze the cofactor-independent decarboxylation of pyruvate. We now report quantum mechanical/molecular mechenical calculations that examine the energetics o ...

Amer Chemical Soc2013

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Chemical specificity

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

Functional characterization of a new tetrachloroethene reductive dehalogenase of Sulfurospirillum spp. identified in mixed cultures

Functional diversity of reductive dehalogenases in a bacterial consortium degrading chloroethenes

Functionalization of Nanoparticles for Targeted Cancer Imaging and Diagnosis

Functional polypeptide and hybrid materials: Precision synthesis via alpha-amino acid N-carboxyanhydride polymerization and emerging biomedical applications

Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

Phage Selection of Photoswitchable Peptide Ligands

Comprehensive study of carbon dioxide adsorption in the metal-organic frameworks M-2(dobdc) (M = Mg, Mn, Fe, Co, Ni, Cu, Zn)

Polypeptide inhibitors of urokinase type plasminogen activator

Computational, Structural, and Kinetic Evidence That Vibrio vulnificus FrsA Is Not a Cofactor-Independent Pyruvate Decarboxylase

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Functional diversity of reductive dehalogenases in a bacterial consortium degrading chloroethenes

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

Functionalization of Nanoparticles for Targeted Cancer Imaging and Diagnosis

Computational, Structural, and Kinetic Evidence That Vibrio vulnificus FrsA Is Not a Cofactor-Independent Pyruvate Decarboxylase

Comprehensive study of carbon dioxide adsorption in the metal-organic frameworks M-2(dobdc) (M = Mg, Mn, Fe, Co, Ni, Cu, Zn)

Functional characterization of a new tetrachloroethene reductive dehalogenase of Sulfurospirillum spp. identified in mixed cultures

Functional polypeptide and hybrid materials: Precision synthesis via alpha-amino acid N-carboxyanhydride polymerization and emerging biomedical applications

Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

Polypeptide inhibitors of urokinase type plasminogen activator

Phage Selection of Photoswitchable Peptide Ligands