Glucocorticoid

Applied sciences
Health sciences
Endocrinology
Topics in endocrinology

Related publications (32)

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Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Benjamin Dieter Weger, Meltem Weger

Background: Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficienc ...

2018

Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells

Sandrine Gerber, François Rémi Pierre Noverraz, Daniel Ortiz Trujillo, Luca Szabó, Léo Bühler

The controlled release of small molecular modulators of the immune response from hydrogel microspheres (MS) used for cell immobilization is an attractive approach to reduce pericapsular fibrotic overgrowth (PFO) after transplantation. Ketoprofen is a well- ...

2018

Long term programming of psychopathology-like behaviors in male rats by peripubertal stress depends on individual’s glucocorticoid responsiveness to stress

Maria del Carmen Sandi Perez, Sophie Elizabeth Walker

Experience of adversity early in life and dysregulation of hypothalamus–pituitary–adrenocortical (HPA) axis activity are risk factors often independently associated with the development of psychopathological disorders, including depression, PTSD and pathol ...

2018

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Meltem Weger

Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social ...

2018

Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress

Maria del Carmen Sandi Perez, Sophie Elizabeth Walker

Exposure to early adversity is implicated in the development of aggressive behaviour later in life in some but not all individuals. The reasons for the variability in response to such experiences are not clear but may relate to pre‐existing individual diff ...

2018

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

Harm-Anton Klok, Maarten Danial, Frederik Roman Wurm

A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...

2017

Stress, glucocorticoid receptor and social behaviors

Peripuberty, comprising childhood and adolescence, constitutes an important time window in the brain development and maturation. Exposure to prolonged stress during this period has been shown to increase the risk for the development of psychopathologies la ...

EPFL2017

Constitutive differences in habituation of the glucocorticoid response to stress are related to variation in aggression and anxiety-related behaviors

Maria del Carmen Sandi Perez, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Sophie Elizabeth Walker

Glucocorticoids coordinate responses that enable an individual to cope with stressful challenges and, additionally, mediate adaptation following cessation of a stressor. There are important individual differences in the magnitude of glucocorticoid responsi ...

2017

European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters

Kristin Schirmer, Juliane Hollender, Anita Orsolya Hidasi, Kevin Thomas, Melis Muz

Growing concern about the adverse environmental and human health effects of a wide range of micropollutants requires the development of novel tools and approaches to enable holistic monitoring of their occurrence, fate and effects in the aquatic environmen ...

Elsevier Science Bv2017

Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations

Kristin Schirmer, Anita Orsolya Hidasi

Synthetic glucocorticoids (GCs) are potential endocrine disrupting compounds that have been detected in the aquatic environment around the world in the low ng/L (nanomolar) range. GCs are used as immunosuppressants in medicine. It is of high interest wheth ...

Elsevier2017

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