Concept

Glucocorticoid

Related publications (89)

Arene ruthenium and pentamethylcyclopentadienyl rhodium and iridium complexes containing N,O-chelating ligands derived from piroxicam: Synthesis, molecular structure and cytotoxicity

The non-steroidal anti-inflammatory and anti-arthritic drug piroxicam (LH) reacts with arene ruthenium dichloride dimers in refluxing dichloromethane to give the complexes [(eta(6)-arene)Ru(eta(2)-N,O-L)Cl] (3: arene = C6H5Me, 4: arene = p-MeC6H4Pri, 5: ar ...

Elsevier2014

Continuous monitoring of Naproxen by a cytochrome P450-based electrochemical sensor

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Camilla Baj-Rossi

This paper reports the characterization of an electrochemical biosensor for the continuous monitoring of Naproxen based on cytochrome P450. The electrochemical biosensor is based on the drop-casting of multi-walled carbon-nanotubes (MWCNTs) and microsomal ...

Elsevier2014

Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Stamatina Tzanoulinou, Vandana Veenit

Stress during childhood and adolescence enhances the risk of psychopathology later in life. We have previously shown that subjecting male rats to stress during the peripubertal period induces long-lasting effects on emotion and social behaviors. As cortico ...

Frontiers Research Foundation2013

Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A

Li Tang

We encapsulated cyclosporine A (CsA) in poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PEG-PLGA) nanoparticles (NPs) by nanoprecipitation of CsA and PEG-PLGA. The resulting CsA/PEG-PLGA-NPs were

2012

Trait anxiety and post-learning stress do not affect perceptual learning

Michael Herzog, Maria del Carmen Sandi Perez, Aaron Michael Clarke, Carl Kristoffer Aberg

While it is well established that stress can modulate declarative learning, very few studies have investigated the influence of stress on non-declarative learning. Here, we studied the influence of post-learning stress, which effectively modulates declarat ...

Elsevier2012

WhiB5, a Transcriptional Regulator That Contributes to Mycobacterium tuberculosis Virulence and Reactivation

Kai Johnsson, Hirohito Haruki, Monica Rengifo Gonzalez

The proteins belonging to the WhiB superfamily are small global transcriptional regulators typical of actinomycetes. In this paper, we characterize the role of WhiB5, a Mycobacterium tuberculosis protein belonging to this superfamily. A null mutant was con ...

American Society for Microbiology2012

An in vivo neovascularization assay for screening regulators of angiogenesis and assessing their effects on pre-existing vessels

Witold Waldemar Kilarski, Marcin Stefan Zielinski

Therapeutic regulation of tissue vascularization has appeared as an attractive approach to treat a number of human diseases. In vivo neovascularization assays that reflect physiological and pathological formation of neovessels are important in this effort. ...

Springer Netherlands2012

Local glucocorticoid production in the mouse lung is induced by immune cell stimulation

Kristina Schoonjans

Background: Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive steroid hormones, mainly produced by the adrenal glands. However, increasing evidence supports the idea of additional extra-adrenal sources of bioactive GC. The lung epithe ...

Wiley-Blackwell2011

Differential effects of pro- and anti-inflammatory cytokines alone or in combinations on the metabolic profile of astrocytes

Pierre Magistretti, Igor Allaman

We have previously reported that the pro-inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β) induce profound modifications of the metabolic profile of astrocytes. The present study was undertaken to further characterize the eff ...

Wiley-Blackwell2011

Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNFalpha-dependent manner

Kristina Schoonjans

Stringent control of immune responses in the intestinal mucosa is critical for the maintenance of immune homeostasis and prevention of tissue damage, such as observed during inflammatory bowel disease. Intestinal epithelial cells, primarily thought to form ...

2010

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