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We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with increased expression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1). ...
An article reporting statistical evidence for epigenetic transfer of learned behavior has important implications, if true. With random sampling, real effects do not always result in rejection of the null hypothesis, but the reported experiments were unifor ...
Genetics Society of America2014
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Since its introduction 16 years ago, the astrocyte-neuron lactate shuttle (ANLS) model has profoundly modified our understanding of neuroenergetics by bringing a cellular and molecular resolution. Praised or disputed, the concept has never ceased to attrac ...
Existing and future media ecosystems need to cope with the ever-increasing heterogeneity of networks, devices, and user characteristics collectively referred to as (usage) context. The key to address this problem is media adaptation to various and dynamica ...
Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this inf ...
Charge compensation at the interface is a fundamental phenomenon determining the operation conditions of thin-film devices incorporating ferroelectrics. The underlying mechanisms have been thoroughly addressed in perovskite ferroelectrics where the charge ...
That the conclusion based on a data analysis be robust and stable is not merely a desirable feature, it is essential. To merit this quality label, a conclusion must be supported by strong data-based evidence and not simply be a discovery gleaned from a pre ...
Smart specialisation is a policy concept that has enjoyed a short but very exciting life! Elaborated by a group of academic “experts” in 2008, it very quickly made a significant impact on the policy audience, particularly in Europe. Such a success story in ...
Since 2006 structured and evidence based research on injury prevention is conducted under the guidance and support of the International Ski Federation (FIS) within the Injury Surveillance System (ISS). The outcome of this work is used directly by the FIS f ...
Falls are by far the leading cause of fractures and accidents in the home environment. The current Cochrane reviews and other systematic reviews report on more than 200 intervention studies about fall prevention. A recent meta-analysis has summarized the m ...
