Concept

Rhinitis

Related publications (20)

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Jacques Fellay, Flavia Aurelia Shoko Hodel

Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...

Cambridge2024

Fungal Contaminants in Energy Efficient Dwellings: Impact of Ventilation Type and Level of Urbanization

Dusan Licina, Shen Yang

The presence of growing fungi in the indoor environment has been associated with the development of respiratory problems such as asthma or allergic rhinitis, as well as the worsening of respiratory pathologies. Their proliferation indoors could be a result ...

2020

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery

Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...

WILEY2019

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Kai Johnsson

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain(1,2). ...

NATURE PUBLISHING GROUP2018

Microbiome and Allergy

Nicola Harris

Allergic diseases including asthma, rhinitis, and food allergies affect an ever-increasing number of patients particularly in industrialized countries. Despite a role for genetic susceptibility in the development of allergies, environmental factors are inc ...

Academic Press2016

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Jacques Rougemont, Laure Menin, Nicola Harris, Alessandra Piersigilli, Benjamin John Marsland, Mario Michael Zaiss, Ilaria Mosconi, Lalit Kumar Dubey, Alexis Rapin, Luc Xavier Marie Lebon, Andrew J. Macpherson

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...

Elsevier2015

Microbiological characterization of 3193 French dwellings of Elfe cohort children

François Gillet

Although exposure to indoor microorganisms in early life has already been associated with respiratory illness or allergy protection, only a few studies have performed standardized samplings and specific microbial analysis. Moreover, most do not target the ...

Elsevier2015

Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation

Nicola Harris, Benjamin John Marsland, Ilaria Mosconi

BackgroundThymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T-helper 2 (Th2)-type responses. However, TSLP has pleiotropic effects upon immune cells, and although extens ...

Wiley-Blackwell2014

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Eva Sabrina Gollwitzer, Nicola Harris, Benjamin John Marsland

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the ...

Nature Publishing Group2014

Antibodies and IL-3 support helminth-induced basophil expansion

Nicola Harris, Mario Michael Zaiss, Manuel Kulagin, Tina Herbst

Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknow ...

Natl Acad Sciences2012

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