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Related publications (73)

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unpre ...

Berlin2024

Influence of macular pigment on the sensitivity to discomfort glare from daylight

Marilyne Andersen, Jan Wienold, Sneha Jain

Understanding the factors that influence the human perception of glare is necessary to properly address glare risks in buildings and achieve comfortable visual environments, especially in the workplace. Yet large inter-individual variabilities in glare per ...

2023

Evaluating contrast sensitivity in early and intermediate age-related Macular Degeneration with the Quick Contrast Sensitivity Function

Michael Herzog, Simona Adele Garobbio

Purpose: The purpose of this study was to describe, validate, and compare the contrast sensitivity functions (CSFs) acquired with the novel quick CSF (qCSF) method from patients with early and intermediate age-related macular degeneration (eAMD and iAMD) a ...

2023

Incomplete Recovery of Zebrafish Retina Following Cryoinjury

Dylan Lawless

Zebrafish show an extraordinary potential for regeneration in several organs from fins to central nervous system. Most impressively, the outcome of an injury results in a near perfect regeneration and a full functional recovery. Indeed, among the various i ...

MDPI2022

Quantification of light exposure characteristics modulating non-visual responses with light-dosimetry

Marilyne Andersen, Steffen Lutz Hartmeyer

(1) Background: Extensive laboratory research has shown that physiological and behavioural responses to light are modulated by different light exposure characteristics, that is, spectral composition, intensity, duration, timing, temporal dynamics, prior hi ...

2022

Random conical tilt reconstruction without particle picking in cryo-electron microscopy

Nicolas Boumal

A method is proposed to reconstruct the 3D molecular structure from micrographs collected at just one sample tilt angle in the random conical tilt scheme in cryo-electron microscopy. The method uses autocorrelation analysis on the micrographs to estimate f ...

INT UNION CRYSTALLOGRAPHY2022

Homogeneous light stimulation of melanopsin and cones with a Maxwellian view device for the human eye

We designed and tested a device to stimulate specifically one photoreceptor type, or a combination of some of them, of the human eye by using up to six primaries. The device produces a homogeneous light field over 40 degrees which is projected onto the ret ...

IEEE2021

Validation of Spectral Simulation Tools for the Prediction of Indoor Daylight Exposure

Marilyne Andersen, Clotilde Marie A Pierson

A growing area of research focuses on the relationship between ocular light exposure and the non-visual responses. In order to accelerate research on this topic and improve building design, reliable spectral simulation tools are needed. This study aims at ...

2021

Adaptive Trade-off between Sensitivity and Spatial Resolution and its Implications for Motion Discrimination and Segregation

Michael Herzog

The success of species depends critically on their ability to process and extract sensory information under a wide range of ecological conditions. For example, on a normal day, the luminance impinging on the retina varies within a dynamic range of 220 dB. ...

2021

Photovoltaic stimulation of retinal microcircuit for vision restoration

Naïg Aurelia Ludmilla Chenais

Sight restoration through retinal prostheses was still a mere dream a century ago. Current challenges are even greater: providing a quantitatively and qualitatively useful artificial vision to late blind patients. Existing approaches all face engineering a ...

EPFL2021

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