Concept

Amyloidosis

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Amyloidosis

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The Role of γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of γ-Secretase Activity and Amyloid-β Generation

Novel Mechanistic Insight into the Molecular Basis of Amyloid Polymorphism and Secondary Nucleation during Amyloid Formation

Specificity and Regulation of the Endoplasmic Reticulum-Associated Degradation Machinery

A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

Imaging brain amyloid deposition using grating-based differential phase contrast tomography

Investigation of Biophysical Properties of Biomolecules by Means of Atomic Force Microscopy

Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease