Concept
Glucose 6-phosphate
Related publications (112)
SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells
Loïc Dayon, Andreas Wiederkehr
Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...
COMPANY BIOLOGISTS LTD2023Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling
Felix Naef, Nicholas Edward Phillips
Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart rate variability (HRV) in ...
CELL PRESS2023Role of the cystathionine beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome
Background: Overexpression of the transsulfuration enzyme cystathionine-beta-synthase (CBS), and overproduction of its product, hydrogen sulfide (H2S) are recognized as potential pathogenetic factors in Down syndrome (DS). The purpose of the study was to d ...
ELSEVIER2022Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias
Johannes Gräff, Giulia Santoni
Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify defici ...
WILEY2022Bioengineering a glucose oxidase nanosensor for near-infrared continuous glucose monitoring
Ardemis Anoush Boghossian, Hanxuan Wang, Vitalijs Zubkovs
Single-walled carbon nanotubes (SWCNTs) emit photostable near-infrared fluorescence that is conducive for optical glucose monitoring. Such SWCNT-based optical sensors often require the immobilization of proteins that can confer glucose selectivity and reac ...
2022Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
Kei Sakamoto, Katyayanee Neopane
SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) inhibitor relative to the widely used, but promiscuous inhibitor Compou ...
2021Decorated graphene oxide flakes with integrated complex of 8-hydroxyquinoline/NiO toward accurate detection of glucose at physiological conditions
Ulf Anders Hagfeldt, Seyyed Alireza Hashemi
The dramatic increase in the number of diabetic people raised the requirement for developing practical diagnostic setups capable of rapid and precise detection of glucose molecules at physiological conditions through non-enzymatic approaches. To address th ...
ELSEVIER SCIENCE SA2021Magnitude of gluconeogenesis and endogenous glucose production: are they predictable in clinical settings?
Introduction: Regulation of endogenous glucose production (EGP) is essential for glucose homeostasis. It includes gluconeogenesis (GNG) from non-carbohydrate substrates and hepatic glycogenolysis. Both these pathways are dysregulated in acute stress, but t ...
2021Design and modelling of a tubular dielectric elastomer actuator with constrained radial displacement as a cardiac assist device
Yves Perriard, Yoan René Cyrille Civet, Armando Matthieu Walter, Jonathan André Jean-Marie Chavanne
In this paper, we propose an improvement of a dielectric elastomer actuator (DEA) based augmented aorta. The actuator is a multi-layered tubular DEA subject to the internal pressure of the blood. When activated in synchronisation with the heart, the DEA su ...
IOP PUBLISHING LTD2021Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Loïc Dayon, Andreas Wiederkehr, Sofia Moco, Isabelle Chareyron
Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...
2020