Publications related to Toll-like receptor

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Jacques Fellay, Yu Zhang, Peng Zhang, Qian Zhang

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvac ...

BMC2023

The cGAS-STING pathway and cancer

Andrea Ablasser, Natasha Ella Samson

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tumori ...

NATURE PORTFOLIO2022

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

Maartje Martina Cornelia Bastings, Alice Comberlato, Marianna Mainardi Koga

First evidence of geometrical patterns and defined distances of biomolecules as fundamental parameters to regulate receptor binding and cell signaling have emerged recently. Here, we demonstrate the importance of controlled nanospacing of immunostimulatory ...

AMER CHEMICAL SOC2022

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

Didier Trono, Priscilla Turelli, Marc Emmenegger

The clinical outcome of SARS-CoV-2 infections, which can range from asymptomatic to lethal, is crucially shaped by the concentration of antiviral antibodies and by their affinity to their targets. However, the affinity of polyclonal antibody responses in p ...

LIFE SCIENCE ALLIANCE LLC2022

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

Bruno Lemaitre, Mark Austin Hanson, Alexia Laurie Carboni

Cecropins are small helical secreted peptides with antimicrobial activity that are widely distributed among insects. Genes encoding Cecropins are strongly induced upon infection, pointing to their role in host defense. In Drosophila, four cecropin genes cl ...

OXFORD UNIV PRESS INC2022

The Drosophila Baramicin polypeptide gene protects against fungal infection

Bruno Lemaitre, Mark Austin Hanson, Igor Iatsenko, Alice Marra

The fruit fly Drosophila melanogaster combats microbial infection by producing a battery of effector peptides that are secreted into the haemolymph. Technical difficulties prevented the investigation of these short effector genes until the recent advent of ...

PUBLIC LIBRARY SCIENCE2021

Advances in the development of entry inhibitors for sialic-acid-targeting viruses

Francesco Stellacci, Matteo Gasbarri, Özgün Kocabiyik

Over the past decades, several antiviral drugs have been developed to treat a range of infections. Yet the number of treatable viral infections is still limited, and resistance to current drug regimens is an ever-growing problem. Therefore, additional stra ...

ELSEVIER SCI LTD2021

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

Bruno Lemaitre, Samuel Rommelaere, Fanny Schüpfer, Florent François Masson, Alice Marra

Insects are frequently infected with heritable bacterial endosymbionts. Endosymbionts have a dramatic impact on their host physiology and evolution. Their tissue distribution is variable with some species being housed intracellularly, some extracellularly ...

2021

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Toll-like receptor

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus

DNA-based biomaterials for nanoscale controlled modulation of immune cells

The cGAS-STING pathway and cancer

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

The Drosophila Baramicin polypeptide gene protects against fungal infection

Advances in the development of entry inhibitors for sialic-acid-targeting viruses

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

Graph Chatbot

Chat with Graph Search

Induction of a strong and long-lasting neutralizing immune response by dPreS1-TLR2 agonist nanovaccine against hepatitis B virus

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

The cGAS-STING pathway and cancer

DNA-based biomaterials for nanoscale controlled modulation of immune cells

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

Advances in the development of entry inhibitors for sialic-acid-targeting viruses

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

The Drosophila Baramicin polypeptide gene protects against fungal infection