Publications related to Enzyme inhibitor

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

Pierre Gönczy, Maria Josefina Marcaida Lopez, Sachin Kotak, Jean-Louis Reymond

Here we report the discovery of a selective inhibitor of Aurora A, a key regulator of cell division and potential anticancer target. We used the atom category extended ligand overlap score (xLOS), a 3D ligand-based virtual screening method recently develop ...

2016

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser

Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; 2 min) elicits a NMDA-dependent death in 65% of mouse cortical neurons in culture ...

2016

Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface

Oliver Hantschel, Allan Joaquim Lamontanara, Barbara Gerig

Bcr-Abl is a constitutively active kinase that causes chronic myelogenous leukemia. We have shown that a tandem fusion of two designed binding proteins, termed monobodies, directed to the interaction interface between the Src homology 2 (SH2) and kinase do ...

American Society for Biochemistry and Molecular Biology2016

Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase

Jeffrey David Jensen

Neuraminidase (NA) inhibitors are used for the prevention and treatment of influenza A virus infections. Two subtypes of NA, N1 and N2, predominate in viruses that infect humans, but differential patterns of drug resistance have emerged in each subtype des ...

Amer Chemical Soc2016

On the Use of Shape-Constrained Splines for Biokinetic Process Modelling

Dominique Bonvin, Julien Léo Billeter, Sriniketh Srinivasan

Identification of mathematical models is an important task for the design and the optimization of biokinetic processes. Monod or Tessier growth-rate models are often chosen by default, although these models are not able to represent the dynamics of all bac ...

Elsevier Science Bv2016

Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Yuhei Takado, Emine Can

The γ-glutamyl transpeptidase (GGT) enzyme plays a central role in glutathione homeostasis. Direct detection of GGT activity could provide critical information for the diagnosis of several pathologies. We propose a new molecular probe, γ-Glu-[1-(13) C]Gly, ...

Wiley-Blackwell2016

Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes

Giovanni De Micheli, Sandro Carrara

Unexplored electrochemical behavior of abiraterone, a recent and widely used prostate cancer drug, in interaction with cytochrome P450 3A4 (CYP3A4) enzyme and multiwalled carbon nanotubes (MWCNTs) is investigated in this work. The results reported in this ...

Amer Chemical Soc2016

Evolution of microbial communities and nutrient removal performances in aerobic granular sludge sequencing batch reactor during change of substrate

Christof Holliger, Julien Maillard, Aline Sondra Adler, Valérie Berclaz, Marie Christelle Horisberger

• Aerobic granular sludge (AGS) is a promising alternative wastewater treatment to the conventional activated sludge system. As AGS has enhanced settling abilities and provides different redox conditions across the granules at the same time, the processes ...

2016

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Enzyme inhibitor

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface

Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase

On the Use of Shape-Constrained Splines for Biokinetic Process Modelling

Racemization of undesired enantiomers: Immobilization of mandelate racemase and application in a fixed bed reactor

Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe

Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes

Evolution of microbial communities and nutrient removal performances in aerobic granular sludge sequencing batch reactor during change of substrate

Graph Chatbot

Chat with Graph Search

Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase

Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe

Enzymatic and Nonenzymatic Electrochemical Interaction of Abiraterone (Antiprostate Cancer Drug) with Multiwalled Carbon Nanotube Bioelectrodes

Racemization of undesired enantiomers: Immobilization of mandelate racemase and application in a fixed bed reactor

On the Use of Shape-Constrained Splines for Biokinetic Process Modelling

Evolution of microbial communities and nutrient removal performances in aerobic granular sludge sequencing batch reactor during change of substrate

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening