Concept

Allergy

Related publications (39)

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

Nicola Harris, Benjamin John Marsland, Tina Herbst

RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora. OBJECTIVES: To ascertain the relevance of commensal bacteria upo ...

2011

Lack of IL-2 in PPAR-alpha deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

Johan Auwerx, Kristina Schoonjans

The aim of the present work was to decipher the cellular basis of the immuno-regulatory role of peroxisome proliferator-activated receptor (PPAR)-alpha in cutaneous hypersensitivity reactions. After challenge with a contact allergen, we observed augmented ...

2011

Human exposure to allergenic pollens: A comparison between urban and rural areas

François Gillet

Background: Pollinosis is found more frequently in urban areas than in rural environments. This could be partly related to the different types of pollen exposure in these dissimilar areas. The objective of this study was to compare the distribution of poll ...

Elsevier2011

Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function

Nicola Harris, Benjamin John Marsland

Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, mainly expressed by epithelial cells, and key to the development of allergic responses. The well-documented involvement of TSLP in allergy has led to the conviction that TSLP promo ...

2009

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

Bruno Lemaitre, Valentin Sottas

The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form of the cytokine-like molecule Spätzle. During the immune response, Spätzle is processed by complex cascades of serine proteases, ...

National Academy of Sciences2009

Organic dyes with a novel anchoring group for dye-sensitized solar cell applications

Michael Graetzel, Mohammad Khaja Nazeeruddin

Two novel trialkylsilyl-containing organic sensitizers (JK-53 and JK-54) have been designed and synthesized. Nanocrystalline TiO2-silica-based dye-sensitized solar cells (DSSCs) were fabricated using these dyes. Under standard global AM 1.5 solar condition ...

Elsevier2009

Solder Doped Polycaprolactone Scaffold Enables Solder Doped Polycaprolactone Scaffold Enables. Reproducible Laser Tissue Soldering

Heinrich Hofmann, Alke Fink

During the last 40 years a focus in research was put on sutureless tissue fusion, to handle the limits of conventional suturing such as vascular wall damage due to the enetrating needle, intraluminal foreign body reactions caused by non-absorbable suture m ...

2008

Magnetic Beads Based Immunoaffinity Capillary Electrophoresis of Total Serum IgE with Laser-Induced Fluorescence Detection

Hubert Girault, Xi Zhang, Hong-Xu Chen

A magnetic beads based immunoaffinity capillary electrophoresis method for total Immunoglobulin E quantification in serum has been developed. The method combines speed, automation ability, and minimal sample consumption. Only 1 μL of serum is required whil ...

2008

The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir

Jacques Fellay, Amalio Telenti

The HLA-B 5701 allele is predictive of hypersensitivity reaction to abacavir, a response herein termed "ABC-HSR." This study of 1,103 individuals infected with human immunodeficiency virus assessed the usefulness of genotyping a HCP5 single-nucleotide poly ...

University of Chicago Press2008

Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate

Johan Auwerx

In the present study, we have assessed the effect of the peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist fenofibrate on allergen-induced airway inflammation and immune response. C57BL/6 or PPARalpha knock-out (PPARalpha(-/-)) mice were ...

2007

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