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Concept
Bioelectricity
Summary
In developmental biology, bioelectricity refers to the regulation of cell, tissue, and organ-level patterning and behavior as the result of endogenous electrically mediated signalling. Cells and tissues of all types use ion fluxes to communicate electrically. The charge carrier in bioelectricity is the ion (charged atom), and an electric current and field is generated whenever a net ion flux occurs. Endogenous electric currents and fields, ion fluxes, and differences in resting potential across tissues comprise a signaling system. It functions alongside (in series and in parallel to) biochemical factors, transcriptional networks, and other physical forces to regulate the cell behavior and large-scale patterning during embryogenesis, regeneration, cancer suppression, and many other processes.
Developmental bioelectricity is a sub-discipline of biology, related to, but distinct from, neurophysiology and bioelectromagnetics. Developmental bioelectricity refers to the endogenous ion fluxes, transmembrane and transepithelial voltage gradients, and electric currents and fields produced and sustained in living cells and tissues. This electrical activity is often used during embryogenesis, regeneration, and cancer suppression—it is one layer of the complex field of signals that impinge upon all cells in vivo and regulate their interactions during pattern formation and maintenance. This is distinct from neural bioelectricity (classically termed electrophysiology), which refers to the rapid and transient spiking in well-recognized excitable cells like neurons and myocytes (muscle cells); and from bioelectromagnetics, which refers to the effects of applied electromagnetic radiation, and endogenous electromagnetics such as biophoton emission and magnetite.
The inside/outside discontinuity at the cell surface enabled by a lipid bilayer membrane (capacitor) is at the core of bioelectricity. The plasma membrane was an indispensable structure for the origin and evolution of life itself.
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Luigi Galvani
Luigi Galvani (ɡælˈvɑːni, also USɡɑːl-; luˈiːdʒi ɡalˈvaːni; Aloysius Galvanus; 9 September 1737 – 4 December 1798) was an Italian physician, physicist, biologist and philosopher, who studied animal electricity. In 1780, he discovered that the muscles of dead frogs' legs twitched when struck by an electrical spark. This was an early study of bioelectricity, following experiments by John Walsh and Hugh Williamson. Luigi Galvani was born to Domenico Galvani and Barbara Caterina Foschi, in Bologna, then part of the Papal States.