Concept

Chromosomal translocation

Related publications (81)

Genetic characterization of CHO production host DG44 and derivative recombinant cell lines

Florian Maria Wurm, David Hacker, Madiha Derouazi, Martin Bertschinger

The dihydrofolate reductase-deficient Chinese hamster ovary (CHO) cell line DG44 is the dominant mammalian host for recombinant protein manufacturing, in large part because of the availability of a well-characterized genetic selection and amplification sys ...

2006

Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells

Ewing's sarcoma is a member of Ewing's family tumors (EFTs) and the second most common solid bone and soft tissue malignancy of children and young adults. It is associated in 85% of cases with the t(11;22)(q24:q12) chromosomal translocation that generates ...

2005

Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes

Denis Duboule

The developmental regulation of vertebrate Hox gene transcription relies on the interplay between local and long-range controls. To study this complex genomic organization, we designed a strategy combining meiotic and targeted recombinations to induce larg ...

2005

Fingering the ends. How to make new telomeres

Joachim Lingner

Telomerase-mediated healing of broken chromosomes gives rise to terminal deletions and is repressed in most organisms. In ciliated protozoa, however, chromosome fragmentation and de novo telomere addition are part of the developmental program. Work by in t ...

2003

Organizing axes in time and space; 25 years of colinear tinkering

Denis Duboule

During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the "Hox clock"). Recent advances in the knowledge of the underlying ...

2003

A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects

Denis Duboule

Mesomelic dysplasia is a severe shortening of forearms and forelegs, and is found in several distinct human syndromes. Here, we report the cloning of the breakpoints of a human t(2;8)(q31;p21) balanced translocation associated with mesomelic dysplasia of t ...

2002

Impact of prenatal diagnosis on the prevalence of live births with Down syndrome in the eastern half of Switzerland 1980-1996

Objectives and Methods: To investigate the impact of prenatal diagnosis on trisomy 2 1 live births, we collected all prenatal and postnatal trisomy 2 1 cases (n = 1096) in the eastern half of Switzerland for the years 1980-1996. Results: Despite increasing ...

2002

Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity

Joachim Lingner

Telomerase is required for the complete replication of chromosomal ends. In tumors, the human telomerase reverse transcriptase subunit (hTERT) is up-regulated, thereby removing a critical barrier for unlimited cell proliferation. To understand more about h ...

2001

Chromosome dynamics in the yeast interphase nucleus

Thierry Laroche

Little is known about the dynamics of chromosomes in interphase nuclei. By tagging four chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored the movement and subnuclear position of specific sites in the yeast genome, s ...

2001

Distribution of HOX genes in the chicken genome reveals a new segment of conservation between human and chicken

Anne Grapin-Botton

Homeobox genes play an important role in the regulation of early embryonic development. They represent a family of evolutionarily highly conserved transcription factors. In this work, several genes that belong to the four HOX gene clusters are assigned by ...

2001

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