Concept

Continuous glucose monitor

Related publications (116)

Role of metabolism and mitochondria during glucose sensing and glucose-induced dysfunction in human pancreatic beta-cells

Glucose sensing and regulation of insulin secretion are the two main functions performed by the pancreatic beta-cell. Together these processes contribute to the tight control of blood glucose in our body. Compromising the ability of the beta-cells to prope ...

EPFL2019

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats

João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares

Diabetes impacts the central nervous system predisposing to cognitive decline. While glucose is the main source of energy fueling the adult brain, brain glycogen is necessary for adequate neuronal function, synaptic plasticity and memory. In this study, we ...

2019

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Cyclodextrins (CDs) are oligosaccharides composed of six (α), seven (β) or eight (γ) glucose units. Their inner hydrophobic cavity and hydrophilic external surface enable the formation of the “host-guest inclusion complex” with different organic or inorgan ...

2019

Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by (1) H-[(13) C] MRS at 14.1T

Rolf Gruetter, Hongxia Lei, Bernard Lanz, João Miguel das Neves Duarte, Antoine Timothée Cherix, Blanca Lizarbe Serra

PURPOSE: Determine the feasibility of (1) H-[(13) C] MRS in the mouse hypothalamus using a 14.1T magnet. METHODS: We optimized the design of a (1) H-[(13) C] surface coil to maximize the signal-to-noise ratio of (1) H-[(13) C] MRS in the mouse hypothalamus ...

2018

Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

Pierre Magistretti, Jocelyne Bloch

Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited. Design: Prospec ...

LIPPINCOTT WILLIAMS & WILKINS2018

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Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple t ...

Wiley-Blackwell2018

Towards Elucidating the Mechanism of Action of Biguanides

Nicolas Peter Goeldel

Diabetes type 2 patients are insensitive to insulin, a condition that leads to reduced glucose uptake by cells and, subsequently, to high concentration of glucose in the blood. For 60 years, biguanides have been one of the few effective therapeutics in red ...

EPFL2018

In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Carole Poitry-Yamate, Marta Lai, Corina Mihaela Berset

In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutam ...

2018

Semantic representation and processing of hypoglycemic events derived from wearable sensor data

Karl Aberer, Jean Paul Calbimonte Perez, Jean-Eudes Marie Ranvier

Diabetes Type 1 is a metabolic disease which results in a lack of insulin production, causing high glucose levels in the blood. It is crucial for diabetic patients to balance this glucose level, and they depend on external substances to do so. In order to ...

Ios Press2017

Glycogen Supercompensation in the Rat Brain After Acute Hypoglycemia is Independent of Glucose Levels During Recovery

Rolf Gruetter, João Miguel das Neves Duarte

Patients with diabetes display a progressive decay in the physiological counter-regulatory response to hypoglycemia, resulting in hypoglycemia unawareness. The mechanism through which the brain adapts to hypoglycemia may involve brain glycogen. We tested t ...

Springer Verlag2017

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