Concept
Extrapyramidal symptoms
Related publications (33)
Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease
To investigate whether the reversible MAO-B inhibitor and sodium channel blocker safinamide impairs glutamate release under parkinsonian conditions in vivo, and this effect is dependent on MAO-B inhibition, safinamide (and rasagiline as a comparator) were ...
PERGAMON-ELSEVIER SCIENCE LTD2020Hallucination Engineering: From Neuroscience Robotics to Hallucinations in Health and Disease
My thesis focuses on a psychotic symptom called the presence hallucination (PH). PHs are defined as the false perception that someone is nearby when no one is actually present. PHs can occur in various populations, ranging from healthy subjects (when expos ...
EPFL2020Autoscopic phenomena as an atypical psychiatric presentation of Huntington's disease: A case report including longitudinal clinical and neuroimaging data
Huntington's disease (HD) is a monogenetic neurodegenerative disease prototypically characterized by the progressive presentation of motor abnormalities, cognitive deterioration and neuropsychiatric symptoms. Even when the disorder is diagnosed based on th ...
2020Dynamic organization of human brain function and its relevance for psychosis vulnerability
The brain is the substrate of a complex dynamic system providing a remarkably varied range of functionalities, going from simple perception to higher-level cognition. Disturbances in its complex dynamics can cause an equally vast variety of mental disorder ...
EPFL2019Gangliosides: Treatment Avenues in Neurodegenerative Disease
Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions. Clinical development of ganglioside replacement therapy for several neurodegenerative ...
FRONTIERS MEDIA SA2019Cortical morphology development in patients with 22q11.2 deletion syndrome at ultra-high risk of psychosis
Maude Schneider, Marie Schaer, Daniela Maria Zöller, Maria Carmela Padula
Background. Patients with 22q11.2 deletion syndrome (22q11DS) present a high risk of developing psychosis. While clinical and cognitive predictors for the conversion towards a full-blown psychotic disorder are well defined and largely used in practice, neu ...
CAMBRIDGE UNIV PRESS2018Apathy and noradrenaline: silent partners to mild cognitive impairment in Parkinson's disease?
Kerstin Preuschoff, Leyla Loued-Khenissi
Purpose of review Mild cognitive impairment (MCI) is a comorbid factor in Parkinson's disease. The aim of this review is to examine the recent neuroimaging findings in the search for Parkinson's disease MCI (PD-MCI) biomarkers to gain insight on whether MC ...
Lippincott, Williams & Wilkins2015The chromatin remodeller Chd7 and the calcium ATPase Serca2 - adding new facets to the role of Notch in Hematopoiesis and T-ALL
Project I: Chd7 Deficiency does not affect N1-driven T-ALL Induction and Maintenance nor impair Hematopoiesis Notch1 has been shown to be a key driver in pediatric T-cell acute lymphobastic leukemia (T-ALL). Previous work in the lab identified the chromati ...
EPFL2015A Randomized Controlled Trial of the Effectiveness of Computer-Assisted Cognitive Remediation (CACR) in Adolescents with Psychosis or at High Risk of Psychosis
Background: Computer assisted cognitive remediation (CACR) was demonstrated to be efficient in improving cognitive deficits in adults with psychosis. However, scarce studies explored the outcome of CACR in adolescents with psychosis or at high risk. Aims: ...
Cambridge University Press2014Graph theory reveals dysconnected hubs in 22q11DS and altered nodal efficiency in patients with hallucinations
Jean-Philippe Thiran, Leila Cammoun, Marie Schaer
Schizophrenia is postulated to be the prototypical dysconnection disorder, in which hallucinations are the core symptom. Due to high heterogeneity in methodology across studies and the clinical phenotype, it remains unclear whether the structural brain dys ...
Frontiers Research Foundation2013