Publications related to Excitatory synapse

Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

Henry Markram, Gilad Silberberg, Daniela Helbig

Inter-pyramidal synaptic connections are characterized by a wide range of EPSP amplitudes. Although repeatedly observed at different brain regions and across layers, little is known about the synaptic characteristics that contribute to this wide range. In ...

2009

Learning flexible sensori-motor mappings in a complex network

Eleni Vasilaki, Walter Senn

Given the complex structure of the brain, how can synaptic plasticity explain the learning and forgetting of associations when these are continuously changing? We address this question by studying different reinforcement learning rules in a multilayer netw ...

Springer Verlag2009

Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held

Ralf Schneggenburger, Olexiy Kochubey, Yunyun Han

Developmental refinement of synaptic transmission can occur via changes in several pre- and postsynaptic factors, but it has been unknown whether the intrinsic Ca2+ sensitivity of vesicle fusion in the nerve terminal can be regulated during development. Us ...

2009

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

Henry Markram, Thomas Berger, Michele Giugliano, Corrado Cali, Michele Pignatelli

Electrical synapses continuously transfer signals bi-directionally from one cell to another, directly or indirectly via intermediate cells. Electrical synapses are common in many brain structures such as the inferior olive, the subcoeruleus nucleus and the ...

Springer US2008

In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time

Rolf Gruetter, Lijing Xin, Giulio Gambarota, Chiara Perazzolo

Glycine is an amino acid present in mammalian brain, where it acts as an inhibitory and excitatory neurotransmitter. The two detectable protons of glycine give rise to a singlet at 3.55 ppm that overlaps with the more intense myo-inositol resonances, and i ...

Wiley-Blackwell2008

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both munc13 and protein kinase C

Ralf Schneggenburger, Natalya Korogod

Diacylglycerol (DAG) and phorbol esters strongly potentiate transmitter release at synapses by activating protein kinase C (PKC) and members of the Munc13 family of presynaptic vesicle priming proteins. This PKC/Munc13 pathway has emerged as a crucial regu ...

Society for Neuroscience2008

Photobleaching-free infrared near-field microscopy localizes molecules in neurons

Giorgio Margaritondo, Kai Johnsson, Harald Hirling, Johanna Generosi, Michel Kropf

High-resolution detection of specific molecules in cells is a major challenge in biology. We show that infrared scanning near-field microscopy can detect the spatial distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid–type glutamate r ...

2008

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study

Pierre Magistretti, Luc Pellerin, Stephanie Clarke

The monocarboxylate transporter MCT2 belongs to a large family of membrane proteins involved in the transport of lactate, pyruvate and ketone bodies. Although its expression in rodent brain has been well documented, the presence of MCT2 in the human brain ...

2008

Slow oscillations in neural networks with facilitating synapses

Henry Markram, Gilad Silberberg

The synchronous oscillatory activity characterizing many neurons in a network is often considered to be a mechanism for representing, binding, conveying, and organizing information. A number of models have been proposed to explain high-frequency oscillatio ...

Springer US2008

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Excitatory synapse

Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

Learning flexible sensori-motor mappings in a complex network

NEURONAL ENRICHED ENDOSOMAL PROTEIN OF 21 kDa COLOCALIZES WITH GLUTAMATE RECEPTOR SUBUNIT GLUR2/3 AT THE POSTSYNAPTIC MEMBRANE

Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both munc13 and protein kinase C

Photobleaching-free infrared near-field microscopy localizes molecules in neurons

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study

Slow oscillations in neural networks with facilitating synapses

Graph Chatbot

Chat with Graph Search

Multiquantal release underlies the distribution of synaptic efficacies in the neocortex

Learning flexible sensori-motor mappings in a complex network

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time

NEURONAL ENRICHED ENDOSOMAL PROTEIN OF 21 kDa COLOCALIZES WITH GLUTAMATE RECEPTOR SUBUNIT GLUR2/3 AT THE POSTSYNAPTIC MEMBRANE

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both munc13 and protein kinase C

Photobleaching-free infrared near-field microscopy localizes molecules in neurons

Slow oscillations in neural networks with facilitating synapses

Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held