Concept

Neural facilitation

Related publications (74)

Mesoscopic population equations for spiking neural networks with synaptic short-term plasticity

Wulfram Gerstner, Tilo Schwalger, Valentin Marc Schmutz

Coarse-graining microscopic models of biological neural networks to obtain mesoscopic models of neural activities is an essential step towards multi-scale models of the brain. Here, we extend a recent theory for mesoscopic population dynamics with static s ...

2020

LTP of inhibition at PV interneuron output synapses requires developmental BMP signaling

Ralf Schneggenburger, Denys Osypenko, Christopher Clark, Evan Dean Vickers

Parvalbumin (PV)-expressing interneurons (PV-INs) mediate well-timed inhibition of cortical principal neurons, and plasticity of these interneurons is involved in map remodeling of primary sensory cortices during critical periods of development. To assess ...

2020

Dendritic Voltage Recordings Explain Paradoxical Synaptic Plasticity: A Modeling Study

Wulfram Gerstner, Matthias Chinyen Tsai, Claire Meissner-Bernard, Laureline Logiaco

Experiments have shown that the same stimulation pattern that causes Long-Term Potentiation in proximal synapses, will induce Long-Term Depression in distal ones. In order to understand these, and other, surprising observations we use a phenomenological mo ...

FRONTIERS RESEARCH FOUNDATION2020

Data-driven integration of hippocampal CA1 synaptic physiology in silico

Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, Armando Romani, András Ecker, Michele Migliore, Szabolcs Kali, Sàra Sàray, Audrey Mercer

The anatomy and physiology of monosynaptic connections in rodent hippocampal CA1 have been extensively studied in recent decades. Yet, the resulting knowledge remains disparate and difficult to reconcile. Here, we present a data-driven approach to integrat ...

2020

Optimal Stimulation Protocol in a Bistable Synaptic Consolidation Model

Wulfram Gerstner, Samuel Pavio Muscinelli, Chiara Gastaldi

Synaptic changes induced by neural activity need to be consolidated to maintain memory over a timescale of hours. In experiments, synaptic consolidation can be induced by repeating a stimulation protocol several times and the effectiveness of consolidation ...

FRONTIERS MEDIA SA2019

Stability of working memory in continuous attractor networks under the control of short-term plasticity

Wulfram Gerstner, Alexander Kevin Seeholzer, Moritz Deger

Continuous attractor models of working-memory store continuous-valued information in continuous state-spaces, but are sensitive to noise processes that degrade memory retention. Short-term synaptic plasticity of recurrent synapses has previously been shown ...

PUBLIC LIBRARY SCIENCE2019

Response Adaptation in Barrel Cortical Neurons Facilitates Stimulus Detection during Rhythmic Whisker Stimulation in Anesthetized Mice

Natali Barros Zulaica

Rodents use rhythmic whisker movements at frequencies between 4 and 12 Hz to sense the environment that will be disturbed when the animal touches an object. The aim of this work is to study the response adaptation to rhythmic whisker stimulation trains at ...

Society for Neuroscience2019

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Rodrigo de Campos Perin, Natali Barros Zulaica, Giuseppe Chindemi

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

2019

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

Graham Knott, Sami El-Boustani

Plasticity of cortical responses in vivo involves activity-dependent changes at synapses, but the manner in which different forms of synaptic plasticity act together to create functional changes in neurons remains unknown. We found that spike timing-induce ...

AMER ASSOC ADVANCEMENT SCIENCE2018

Layer-Dependent Short-Term Synaptic Plasticity Between Excitatory Neurons in the C2 Barrel Column of Mouse Primary Somatosensory Cortex

Carl Petersen, Sandrine Lefort

Neurons process information through spatiotemporal integration of synaptic input. Synaptic transmission between any given pair of neurons is typically a dynamic process with presynaptic action potentials (APs) evoking depressing or facilitating postsynapti ...

Oxford Univ Press Inc2017

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