Concept

Radial glial cell

Related publications (162)

Remodeling of peripheral nerve ensheathment during the larval-to-adult transition in Drosophila

Over the course of a 4-day period of metamorphosis, the Drosophila larval nervous system is remodeled to prepare for adult-specific behaviors. One example is the reorganization of peripheral nerves in the abdomen, where five pairs of abdominal nerves (A4-A ...

Wiley2017

Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex

Michele Giugliano

Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and di ...

Cell Press2017

Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex

Johannes Gräff, Jose Vicente Sanchez Mut

The brain's neocortex is anatomically organized into grey and white matter, which are mainly composed by neuronal and glial cells, respectively. The neocortex can be further divided in different Brodmann areas according to their cytoarchitectural organizat ...

Wiley-Blackwell2017

In vivo cerebral metabolism of glioblastoma xenografts assessed with ¹H MRS, ¹³C MRS and ¹⁸F-FDG PET

Marta Lai

Magnetic resonance spectroscopy (MRS) is a powerful tool when studying metabolism in intact and living organs preserving cells in their natural microenvironment with minimal external interference. The unique insights offered by the observation of metabolic ...

EPFL2017

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

Gioele La Manno

Cell replacement therapies for neurodegenerative disease have focused on transplantation of the cell types affected by the pathological process. Here we describe an alternative strategy for Parkinson's disease in which dopamine neurons are generated by dir ...

2017

AAV based gene therapy for rare diseases

Cylia Cloé Rochat

Of the seven thousand diseases that are described as rare, 80% of them have an identified genetic cause. With this in the mind, the development of technologies, such as gene therapy, to address the genetic factors involved in these pathologies, might be a ...

EPFL2017

Surface-enhanced tractography (SET)

Gabriel Girard, Alessandro Daducci, Maxime Descoteaux

In this work, we exploit the T1 weighted image in conjunction with cortical surface boundary to improve the precision of tractography under the cortex. We show that utilizing the cortical interface and a surface flow, to model the superficial white matter ...

Elsevier2017

Compartmentalised energy metabolism supporting glutamatergic neurotransmission in response to increased activity in the rat cerebral cortex: A 13C MRS study in vivo at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Many tissues exhibit metabolic compartmentation. In the brain, while there is no doubt on the importance of functional compartmentation between neurons and glial cells, there is still debate on the specific regulation of pathways of energy metabolism at di ...

Nature Publishing Group2016

Cellular forces and matrix assembly coordinate fibrous tissue repair

Mahmut Selman Sakar, Daniel Eberli

Planar in vitro models have been invaluable tools to identify the mechanical basis of wound closure. Although these models may recapitulate closure dynamics of epithelial cell sheets, they fail to capture how a wounded fibrous tissue rebuilds its 3D archit ...

2016

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

Gioele La Manno, Jesper Ryge

Understanding human embryonic ventral midbrain is of major interest for Parkinson's disease. However, the cell types, their gene expression dynamics, and their relationship to commonly used rodent models remain to be defined. We performed single-cell RNA s ...

2016

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