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We demonstrate that single-variable integrate-and-fire models can quantitatively capture the dynamics of a physiologically-detailed model for fast-spiking cortical neurons. Through a systematic set of approximations, we reduce the conductance based model t ...
The ability to overexpress full-length huntingtin or large fragments represents an important challenge to mimic Huntington's pathology and reproduce all stages of the disease in a time frame compatible with rodent life span. In the present study, tetracycl ...
This paper first investigates a companded differential pulse-coded modulator and. derives an expression for its SNR performance. Analysis and simulations show that, the coder has superior SNR and dynamic range performance over other coders of similar compl ...
The storage and short-term memory capacities of recurrent neural networks of spiking neurons are investigated. We demonstrate that it is possible to process online many superimposed streams of input. This is despite the fact that the stored information is ...
The rat neural cell line RN33B has a remarkable ability to undergo region-specific neuronal differentiation after transplantation into the CNS. To further study its neurogenic properties in vivo, we used a recombinant lentiviral vector to genetically label ...
The short-term plasticity of synaptic transmission between excitatory neurons within a barrel of layer 4 rat somatosensory neocortex was investigated. Action potentials in presynaptic neurons at frequencies ranging from 1 to 100 Hz evoked depressing postsy ...
Although previous Northern blot and in situ hybridization studies suggested that neurons express the monocarboxylate transporter MCT2, subsequent immunohistochemical analyzes either failed to confirm the presence of this transporter or revealed only a low ...
We investigate the performance of sparsely-connected networks of integrate-and-fire neurons for ultra-short term information processing. We exploit the fact that the population activity of networks with balanced excitation and inhibition can switch from an ...
We investigate the propagation of pulses of spike activity in a neuronal network with feed-forward couplings. The neurons are of the spike-response type with a firing probability that depends linearly on the membrane potential. AFter firing neurons enter a ...
Viral delivery of glial cell line-derived neurotrophic factor (GDNF) currently represents one of the most promising neuroprotective strategies for Parkinson's Disease (PD). However, the effect of this neurotrophic factor has never been tested in the newly ...
