Concept
Acute-phase protein
Related publications (62)
Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme
Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...
Frontiers Media Sa2024Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection
Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Idris Guessous, Alexandre Cionca
Background: A neurocognitive phenotype of post-COVID-19 infection has recently been described that is characterized by a lack of awareness of memory impairment (i.e., anosognosia), altered functional connectivity in the brain's default mode and limbic netw ...
PERGAMON-ELSEVIER SCIENCE LTD2023Tracking spatiotemporal localisation and interactions of the innate immune sensor STING
Innate immunity, the very first line of defence of our cells, relies on the detection of universal pathogen- or danger-associated signals to launch an inflammatory response. A crucial part of our innate immune system is based on the recognition of out-of-c ...
EPFL2023The combined impact of persistent infections and human genetic variation on C-reactive protein levels
Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Clara Bonnet
Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...
BMC2022Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus
Jacques Fellay, Christian Axel Wandall Thorball, Nicolas Meyer
Objective Primary Sjogren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with primary SS, we integrated transcriptom ...
WILEY2022Microfluidic systems for in-flow bioanalytes collection
Microfluidic is an ensemble of technologies and methods that permits the handling and analysis of minute volumes of samples in short timescales. Since its introduction it revealed a remarkable potential to unveil novel biological mechanisms. The small volu ...
EPFL2022C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy
Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 ...
SPRINGER WIEN2021Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by alpha-1 Antitrypsin
Florian Maria Wurm, Divor Kiseljak
For the treatment of severe COVID-19, supplementation with human plasma-purified alpha-1 antitrypsin (AAT) to patients is currently considered. AAT inhibits host proteases that facilitate viral entry and possesses broad anti-inflammatory and immunomodulato ...
MDPI2021Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster
Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko, Alice Marra, Jasquelin Peña
Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...
NATL ACAD SCIENCES2020Arylsilylation of Electron-Deficient Alkenes via Cooperative Photoredox and Nickel Catalysis
Carbosilylation of alkenes can be an efficient approach to the synthesis of organosilicon compounds. However, few general methods of carbosilylation are known. Here, we introduce a strategy for arylsilylation of electron deficient terminal alkenes by combi ...
AMER CHEMICAL SOC2020