Concept
Dermatitis
Related publications (6)
Photoregulated fluxional fluorophores for live-cell super-resolution microscopy with no apparent photobleaching
Photoswitchable mols. have multiple applications in the phys. and life sciences because their properties can be modulated with light. Fluxional mols., which undergo rapid degenerate rearrangements in the electronic ground state, also exhibit switching beha ...
Springer2019Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch
The present invention relates to the use for enhancing Notch signaling in an individual, of a compound showing the general formula (I) and/or a pharmaceutically acceptable salt or ester thereof, for the treatment of a disease selected from the group of der ...
2017The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation
Jacques Rougemont, Laure Menin, Nicola Harris, Alessandra Piersigilli, Benjamin John Marsland, Mario Michael Zaiss, Ilaria Mosconi, Lalit Kumar Dubey, Alexis Rapin, Luc Xavier Marie Lebon, Andrew J. Macpherson
Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...
Elsevier2015Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation
Nicola Harris, Benjamin John Marsland, Ilaria Mosconi
BackgroundThymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T-helper 2 (Th2)-type responses. However, TSLP has pleiotropic effects upon immune cells, and although extens ...
Wiley-Blackwell2014The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells
SPINK5 (serine protease inhibitor Kazal-type 5) encodes the proteinase inhibitor LEKTI (lympho-epithelial Kazal-type related inhibitor). In skin, LEKTI expression is restricted to the stratum granulosum of the epidermis and the inner root sheath of hair fo ...
EPFL2011Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin
Freddy Radtke, Ute Koch, Matteo Di Piazza
BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...
Public Library of Science2010