Concept

Valproate

Related publications (32)

Synthesis and Photophysical Properties of Ln(III)-DOTA-Bipy Complexes and Ln(III)-DOTA-Bipy-Ru-II Coordination Conjugates

The synthesis and the systematic and comparative photo-physical study of a series of visible (Eu-III, Tb-III) and NIR-emitting (Nd-III, Yb-III) lanthanide complexes (Ln(2)L) and ruthenium lanthanide coordination conjugates (Ln(2)LRu) are reported. The Gd-I ...

Wiley-Blackwell2010

Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism

Henry Markram, Kamila Markram, Tania Rinaldi, Jean-Vincent Le Bé, Imad Riachi, Guilherme Silva

A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperco ...

2009

Abnormal fear conditioning and amygdala processing in an animal model of autism

Maria del Carmen Sandi Perez, Henry Markram, Deborah La Mendola, Kamila Markram, Tania Rinaldi

A core feature of autism spectrum disorders is the impairment in social interactions. Among other brain regions, a deficit in amygdala processing has been suggested to underlie this impairment, but whether the amygdala is processing fear abnormally in auti ...

Nature Publishing Group2008

Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic Acid animal model of autism

Henry Markram, Tania Rinaldi, Catherine Perrodin

The prefrontal cortex has been extensively implicated in autism to explain deficits in executive and other higher-order functions related to cognition, language, sociability and emotion. The possible changes at the level of the neuronal microcircuit are ho ...

2008

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Henry Markram, Gilad Silberberg, Tania Rinaldi

Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryo ...

Oxford University Press2008

The intense world syndrome – an alternative hypothesis for autism

Henry Markram, Kamila Markram, Tania Rinaldi

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the ne ...

2007

The role of the amygdala in emotional memories

Maria del Carmen Sandi Perez, Kamila Markram

This thesis investigates the role of the amygdala for the establishment of fear memories with a multidisciplinary approach, including behavioural, psychopharmacological, genetic, molecular, and electrophysiological techniques in rats or mice, under healthy ...

EPFL2007

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Henry Markram, Tania Rinaldi

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...

2007

Altered neocortical microcircuitry in the valproic acid rat model of autism

Tania Rinaldi

Autism is a wide-spectrum disorder with early childhood onset, affecting general cognitive capabilities and, in particular, complex information processing. Although interesting directions of research start to appear, the precise causes of the disorder and ...

EPFL2006

Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production

Patrick Aebischer, Manuel Bauer

Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic system. Brain delivery of glial cell line-derived neurotrophic factor (GDNF) has been shown to protect and restore the dopaminergic pathway in vario ...

2005

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