In estimation theory and statistics, the Cramér–Rao bound (CRB) relates to estimation of a deterministic (fixed, though unknown) parameter. The result is named in honor of Harald Cramér and C. R. Rao, but has also been derived independently by Maurice Fréchet, Georges Darmois, and by Alexander Aitken and Harold Silverstone. It states that the precision of any unbiased estimator is at most the Fisher information; or (equivalently) the reciprocal of the Fisher information is a lower bound on its variance. An unbiased estimator that achieves this bound is said to be (fully) efficient. Such a solution achieves the lowest possible mean squared error among all unbiased methods, and is therefore the minimum variance unbiased (MVU) estimator. However, in some cases, no unbiased technique exists which achieves the bound. This may occur either if for any unbiased estimator, there exists another with a strictly smaller variance, or if an MVU estimator exists, but its variance is strictly greater than the inverse of the Fisher information. The Cramér–Rao bound can also be used to bound the variance of estimators of given bias. In some cases, a biased approach can result in both a variance and a mean squared error that are the unbiased Cramér–Rao lower bound; see estimator bias. The Cramér–Rao bound is stated in this section for several increasingly general cases, beginning with the case in which the parameter is a scalar and its estimator is unbiased. All versions of the bound require certain regularity conditions, which hold for most well-behaved distributions. These conditions are listed later in this section. Suppose is an unknown deterministic parameter that is to be estimated from independent observations (measurements) of , each from a distribution according to some probability density function . The variance of any unbiased estimator of is then bounded by the reciprocal of the Fisher information : where the Fisher information is defined by and is the natural logarithm of the likelihood function for a single sample and denotes the expected value with respect to the density of .