Concept

Directional selection

Related publications (182)

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The Hsp70 cycle is a key element of protein homeostasis, which is essential to avoid protein aggregation and protein-related diseases. Despite many experimental observations of the interaction between Hsp70, its co-chaperone DnaJ and various substrates, li ...

EPFL2023

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Robot motor skills can be acquired by deep reinforcement learning as neural networks to reflect state-action mapping. The selection of states has been demonstrated to be crucial for successful robot motor learning. However, because of the complexity of neu ...

NATURE PORTFOLIO2023

Systematic benchmarking of single-cell ATAC-sequencing protocols

Bart Deplancke, Jörn Pezoldt, Camille Lucie Germaine Lambert

Benchmarking of scATAC-seq protocols demonstrates the effects of data quality on downstream analyses. Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has emerged as a powerful tool for dissecting regulatory landscapes and ...

NATURE PORTFOLIO2023

Microbial community assembly in streams draining proglacial floodplains

Tom Ian Battin, Hannes Markus Peter, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Leïla Ezzat, Massimo Bourquin, Tyler Joe Kohler, Jade Brandani, Stylianos Fodelianakis, Paraskevi Pramateftaki

As glaciers shrink, new terrain is exposed and drained by proglacial streams along both longitudinal and lateral chronosequences which are fed by various water sources (glacier melt, snowmelt, and groundwater). While benthic microbial biofilms often initia ...

2022

The A-to-G point mutation at position 3243 in the human mitochondrial genome (m.3243A > G) is the most common pathogenic mtDNA variant responsible for disease in humans. It is widely accepted that m.3243A > G levels decrease in blood with age, and an age c ...

OXFORD UNIV PRESS2022

A Wasserstein-based measure of conditional dependence

Negar Kiyavash, Seyed Jalal Etesami, Kun Zhang

Measuring conditional dependencies among the variables of a network is of great interest to many disciplines. This paper studies some shortcomings of the existing dependency measures in detecting direct causal influences or their lack of ability for group ...

2022

Many different emission pathways exist that are compatible with the Paris climate agreement, and many more are possible that miss that target. While some of the most complex Earth System Models have simulated a small selection of Shared Socioeconomic Pathw ...

AMER GEOPHYSICAL UNION2022

A minimalistic cyclic ice-binding peptide from phage display

Harm-Anton Klok, Luciano Andres Abriata, Corey Alfred Stevens, Matthew Gibson, Xudong Kong

Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...

2021

The Imitation Game: Algorithm Selection by Exploiting Black-Box Recommenders

Rachid Guerraoui, Georgios Damaskinos

Cross-validation is commonly used to select the recommendation algorithms that will generalize best on yet unknown data. Yet, in many situations the available dataset used for cross-validation is scarce and the selected algorithm might not be the best suit ...

Springer2021

Mutation-based greybox fuzzing-unquestionably the most widely-used fuzzing technique-relies on a set of non-crashing seed inputs (a corpus) to bootstrap the bug-finding process. When evaluating a fuzzer, common approaches for constructing this corpus inclu ...

ASSOC COMPUTING MACHINERY2021