Concept

Hemolytic anemia

Related publications (26)

Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene

Clostridium perfringens phospholipase C (PLC), also called alpha-toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered alpha-toxin variants harboring single amino-acid substitutions in thre ...

2000

Biotechnology in Lausanne. The Rh D project

Urs von Stockar, Florian Maria Wurm, Ian William Marison, Nicolas Mermod

A review is given with 2 refs. Hemolytic disease of the newborn is an often fatal condition of some newborn babies due to the immunogenicity of their Rh D pos. erythrocytes in the Rh D neg. mother. This condition can be prevented by injecting anti-Rh D ant ...

1999

The SPP biotech module 1: proteins for medical applications: a multidisciplinary effort for the development of a recombinant anti-RhD antibody preparation for the prevention of hemolytic disease of the newborn

Urs von Stockar, Florian Maria Wurm, Lucia Baldi Unser, Ian William Marison, Martin Jordan, Patrick Pugeaud, Philippe Pierre Girard, Lisa Hunt

A review with 0 refs. is presented regarding studies of a multidisciplinary team to establish the prophylactic principle and the manufg. process for anti-Rh D therapy based on recombinant antibody prepns. produced from Chinese hamster ovary cells. [on SciF ...

1999

Positional cloning of the zebrafish sauternes gene: A model for congenital sideroblastic anaemia

Andrew Charles Oates

Many human anaemias are caused by defects in haemoglobin synthesis. The zebrafish mutant sauternes (sau) has a microcytic, hypochromic anaemia, suggesting that haemoglobin production is perturbed. During embryogenesis, sau mutants have delayed erythroid ma ...

1998

Use of site-directed mutagenesis to probe structure-function relationships of alpha-toxin from Clostridium perfringens.

Stewart Cole

The NH2-terminal domain of the alpha-toxin of Clostridium perfringens is highly homologous to the complete phospholipase C from Bacillus cereus (PC-PLC), for which a high-resolution crystal structure is available. This structural information was used as th ...

1996

Gene cloning shows the alpha-toxin of Clostridium perfringens to contain both sphingomyelinase and lecithinase activities

Stewart Cole

The plc gene encoding the alpha-toxin (phospholipase C), an important virulence factor of Clostridium perfringens, has been cloned, sequenced and expressed in Escherichia coli. Transcriptional analysis of mRNAs produced in vivo by C. perfringens and E. col ...

1989

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