Concept
Bacterial secretion system
Related publications (68)
The evolution of the type VI secretion system as a disintegration weapon
The type VI secretion system (T6SS) is a nanomachine used by many bacteria to drive a toxin-laden needle into other bacterial cells. Although the potential to influence bacterial competition is clear, the fitness impacts of wielding a T6SS are not well und ...
PUBLIC LIBRARY SCIENCE2020High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis
Stewart Cole, Florence Pojer, Jérémie Piton
The EspB protein of Mycobacterium tuberculosis is a 60 kDa virulence factor, implicated in conjugation and exported by the ESX-1 system of which it may also be a component. Previous attempts to obtain high-resolution maps of EspB by cryo-electron microscop ...
2020Combining Fluidic Devices with Microscopy and Flow Cytometry to Study Microbial Transport in Porous Media Across Spatial Scales
Tom Ian Battin, Hannes Markus Peter, David Scheidweiler
Understanding the transport, dispersion and deposition of microorganisms in porous media is a complex scientific task comprising topics as diverse as hydrodynamics, ecology and environmental engineering. Modeling bacterial transport in porous environments ...
2020Label-free plasmonic biosensors for real-time live cell analysis
For decades, the understanding of life has been focused on its most fundamental building blocks: molecules. Deciphering the dynamic activities of protein molecules in human cells is of vital significance for fundamental and clinical studies. The minuscule ...
EPFL2019Resonant optical trapping in hollow photonic crystal cavities and its potential use for bacterial characterisation
During the last decade, the development of optofluidic chips has become a large field of research. The integration of nano and microstructures with microfluidics layers allowed for the miniaturisation of a number of tools traditionally used in laboratories ...
EPFL2019Two nanomachines drive evolution in diverse Vibrio species
Horizontal gene transfer (HGT) has a major impact on bacterial evolution, leading to acquisition or deletion of genes and gene clusters, including those encoding antibiotic resistances and virulence factors. HGT therefore contributes to pathogen emergence, ...
EPFL2019Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis
Tuberculosis (TB) is a chronic infectious disease that mainly affects the lungs and causes extensive human morbidity and mortality. It results from infection with Mycobacterium tuberculosis, a slow-growing intracellular pathogen that can replicate and surv ...
EPFL2018Bacterial type VI secretion system facilitates niche domination
Melanie Blokesch, Natalia Carolina Drebes Dorr
Over the last few decades humanity has experienced a series of tremendous technological advances, especially in the realm of basic science. A plethora of new approaches has allowed us to appreciate life in previously unimaginable detail, prompting the real ...
2018Inner-membrane GspF of the bacterial type II secretion system is a dimeric adaptor mediating pseudopilus biogenesis
The type II secretion system (T2SS), a protein complex spanning the bacterial envelope, is pivotal to bacterial pathogenicity. Central to T2SS function is the extrusion of protein cargos from the periplasm into the extracellular environment mediated by a p ...
2018Structural and functional analysis of host attachment proteins from contractile injection systems
Bacteriophages of the myoviridae family, R-type pyocin, Photorhabus virulence cassette (PVC), Serratia antifeeding prophage (Afp) and type 6 secretion system (T6SS) form a class of contractile injection systems that share common structural and functional c ...
EPFL2018