Vascular surgery

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Sensor-integrated ultraflexible endovascular devices

Medical interventions in the central nervous system (CNS) are challenging due to the complexity and delicacy of the brain tissue. Techniques that do not require opening the skull would alleviate patient discomfort and increase post-operative outputs. Vesse ...

EPFL2022

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer

Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...

FRONTIERS MEDIA SA2022

Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation

Adele Fanelli

Transient electronics enabling devices to safely disappear in the environment can be applied not only in green electronics, but also in bioelectronic medicine. Neural implants able to degrade harmlessly inside the body eliminate the need for removal surger ...

EPFL2022

p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Allancer Divino De Carvalho Nunes

Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

Oriane Poupart

Intracranial aneurysm is a cerebrovascular disease characterized by an artery dilation in the brain. An aneurysm is prone to rupture, which causes a life-threatening subarachnoid hemorrhage. The major drawbacks of the current treatments, open surgical clip ...

EPFL2021

Transient Neurovascular Interface for Minimally Invasive Neural Recording and Stimulation

Diego Ghezzi, Philippe Reymond, Laura Ferlauto, Adele Fanelli, Elodie Geneviève Zollinger

Neural interfaces are used to mitigate the burden of traumatic injuries, neurodegenerative diseases, and mental disorders. However, the transient or permanent placement of an interface in close contact with the neural tissue requires invasive surgery, pote ...

Wiley2021

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Dominique Pioletti, Christophe Moser, Mahmut Selman Sakar, Andreas Schmocker, Oriane Poupart, Lucio Feo Pancaldi-Giubbini

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

2021

Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet

Nikolaos Stergiopoulos

Aims B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. ...

OXFORD UNIV PRESS2021

Deep Learning Building on Prior Ischemic Core Segmentation Improves Prediction of Infarction After Stroke

Dimitri Nestor Alice Van De Ville, Elisabeth Anne Dirren, Maria Giulia Preti, Guillaume Paul Olivier Leclerc

Introduction: Imaging studies are used to guide patient selection for acute stroke treatment. Perfusion CT (pCT) is widely used to identify the acute ischemic core and penumbra, but the prediction of the final infarct remains challenging. With the advent o ...

LIPPINCOTT WILLIAMS & WILKINS2021

The perspectives of mapping and monitoring of the sense of self in neurosurgical patients

Olaf Blanke, Bruno Herbelin, Hyeongdong Park, Sophie Jacqueline Andrée Betka, Pavo Orepic, Sixto Luis Alcoba Banqueri, Giannina Rita Iannotti

Surgical treatment of tumors, epileptic foci or of vascular origin, requires a detailed individual pre-surgical workup and intra-operative surveillance of brain functions to minimize the risk of post-surgical neurological deficits and decline of quality of ...

SPRINGER WIEN2021

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OXFORD UNIV PRESS2021