Messina (mɛˈsiːnə , USalsomᵻˈ- , mesˈsiːna; Missina mɪsˈsiːna) is a harbour city and the capital of the Italian Metropolitan City of Messina. It is the third largest city on the island of Sicily, and the 13th largest city in Italy, with a population of more than 219,000 inhabitants in the city proper and about 650,000 in the Metropolitan City. It is located near the northeast corner of Sicily, at the Strait of Messina and it is an important access terminal to Calabria region, Villa San Giovanni, Reggio Calabria on the mainland. According to Eurostat the FUA of the metropolitan area of Messina has, in 2014, 277,584 inhabitants. The city's main resources are its seaports (commercial and military shipyards), cruise tourism, commerce, and agriculture (wine production and cultivating lemons, oranges, mandarin oranges, and olives). The city has been a Roman Catholic Archdiocese and Archimandrite seat since 1548 and is home to a locally important international fair. The city has the University of Messina, founded in 1548 by Ignatius of Loyola. Timeline of Messina Founded by Greek colonists of Magna Graecia in the 8th century BC, Messina was originally called Zancle (Ζάγκλη), from the Greek ζάγκλον meaning "scythe" because of the shape of its natural harbour (though a legend attributes the name to King Zanclus). A comune of its Metropolitan City, located at the southern entrance of the Strait of Messina, is to this day called 'Scaletta Zanclea'. Solinus wrote that the city of Metauros was established by people from Zancle. In the early 5th century BC, Anaxilas of Rhegium renamed it Messene (Μεσσήνη) in honour of the Greek city Messene (See also List of traditional Greek place names). Later, Micythus was the ruler of Rhegium and Zancle, and he also founded the city of Pyxus. The city was sacked in 397 BC by the Carthaginians and then reconquered by Dionysius I of Syracuse. In 288 BC the Mamertines seized the city by treachery, killing all the men and taking the women as their wives.