Concept
Blood protein
Related publications (41)
Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation
Antonia Neels, Marianne Liebi, Tiberiu Totu
Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a ple ...
Elsevier2024Plasma biomarkers for Alzheimer's disease: a field-test in a memory clinic
Background The key Alzheimer's disease (AD) biomarkers are traditionally measured with techniques/exams that are either expensive (amyloid-positron emission tomography (PET) and tau-PET), invasive (cerebrospinal fluid A beta 42 and p-tau 181), or poorly sp ...
BMJ PUBLISHING GROUP2023Molecular analysis and therapeutic applications of human serum albumin-fatty acid interactions
Alessandro Angelini, Alessandro Zorzi, Sara Linciano
Human serum albumin (hSA) is the major carrier protein for fatty acids (FAs) in plasma. Its ability to bind multiple FA moieties with moderate to high affinity has inspired the use of FA conjugation as a safe and natural platform to generate long-lasting t ...
ELSEVIER2022Proteomics reveals unique plasma signatures in constitutional thinness
Loïc Dayon, Jörg Hager, Nele Gheldof
Purpose Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and dis ...
WILEY-V C H VERLAG GMBH2022Hybrid Transcriptional Regulators for the Screening of Target DNA Motifs in Organohalide-Respiring Bacteria
Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin, Marie Vingerhoets
The bioremediation of persistent organohalide molecules under anoxic conditions mostly relies on the bacterial process called organohalide respiration (OHR). Organohalide-respiring bacteria (OHRB) are phylogenetically diverse anaerobic bacteria that share ...
2020Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device
Hatice Altug, Filiz Yesilköy, Alexander Belushkin
Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Here we report a portable PoC devi ...
AMER CHEMICAL SOC2019Microdevice for Sedimentation-based Separation of Blood Microsamples at the Point of Collection
Laboratory blood testing plays a central role in current diagnostics and therapeutical decisions. Thus, errors have a direct impact on care quality and cost. The majority of errors occur in the pre-analytical phase, when samples are collected, stored and p ...
EPFL2017Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity
Christian Heinis, Jonas Alfred Karl Wilbs, Simon Jan Middendorp
Factor XII (FXII) is a plasma protease that has emerged in recent years as a potential target to treat or prevent pathological thrombosis, to inhibit contact activation in extracorporeal circulation, and to treat the swelling disorder hereditary angioedema ...
2017Molecular chaperones inject energy from ATP hydrolysis into the non-equilibrium stabilisation of native proteins
Paolo De Los Rios, Alessandro Barducci, Pierre Goloubinoff, Bruno Claude Daniel Fauvet, Alberto Stefano Sassi
Protein homeostasis, namely the ensemble of cellular mechanisms collectively controlling the activity, stability and conformational states of proteins, depends on energy-consuming processes. De novo protein synthesis requires ATP hydrolysis for peptide bon ...
2017Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events
Jeffrey Alan Hubbell, Melody Swartz, Hans Mattias Larsson, Lambert Charles François Potin, Gabriele Galliverti, Jun Ishihara, Kazuto Fukunaga
Immune checkpoint blockade exhibits considerable antitumor activity, but previous studies have reported instances of severe treatment-related adverse events. We sought to explore local immune checkpoint blockade, with an antibody (Ab) form that would be re ...
Amer Assoc Advancement Science2017