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The interplay between dopamine and alpha-synuclein (AS) plays a central role in Parkinson's disease (PD). PD results primarily from a severe and selective devastation of dopaminergic neurons in substantia nigra pars compacta. The neuropathological hallmark ...
Dysfunction of the central dopaminergic system is associated with neurodegenerative disorders and mental illnesses such as Parkinson's disease and schizophrenia. Patients suffering from these diseases were reported to exhibit altered immune functions compa ...
Objectives: The aim of the study was to examine whether the postpsychotic decline in IQ during schizophrenia coincides with psychopathological deterioration or it is a state-independent premorbid impairment. Methods: The IQ score of 32 schizophrenic patien ...
Machado-Joseph disease (MJD) is a fatal, dominant neurodegenerative disorder. MJD results from polyglutamine repeat expansion in the MJD-1 gene, conferring a toxic gain of function to the ataxin-3 protein. In this study, we aimed at overexpressing ataxin-3 ...
Handwriting in Parkinson's disease (PD) is typically characterized by micrographia, jagged line contour, and unusual fluctuations in pen tip velocity. Although PD handwriting features have been used for diagnostics, they are not based on a signaling model ...
We review recent rain-scanning (fMRI) evidence that activity in certain sub-cortical structures of the human brain correlate with changes in expected reward, as well as with risk. Risk is measured by variance of payoff, as in Markowitz' theory. The brain s ...
Background The dysconnection hypothesis has been proposed to account for pathophysiological mechanisms underlying schizophrenia. Widespread structural changes suggesting abnormal connectivity in schizophrenia have been imaged. A functional counterpart of t ...
Schizophrenic patients show aberrancies of contextual processing over a broad range. Of particular importance are low level contextual deficiencies since they might cause higher level processing deficits. It was previously found that schizophrenic patients ...
The recent spate of neuroimaging studies on decision-making under uncertainty has provided converging evidence of a spatio-temporal dissociation of risk and expected reward encoding in the human brain. While this research has demonstrated widespread hemody ...
Glial cell line-derived neurotrophic factor (GDNF) has been shown to increase the survival and functioning of dopamine neurons in a variety of animal models and some recent human trials. However, delivery of any protein to the brain remains a challenge due ...