Publications related to Lymphatic filariasis

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

NATURE PUBLISHING GROUP2020

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Marco Pisano, Melody Swartz, Witold Waldemar Kilarski

Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors ...

Springer2019

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Nicola Harris, Lalit Kumar Dubey, Praneeth Karempudi

Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation. Here we demonstrate a crucial role for lymphotoxin-beta receptor (LT beta R) signalin ...

Springer Nature2017

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Melody Swartz, Patrycja Nowak-Sliwinska, Witold Waldemar Kilarski, Renata Katarzyna Mezyk-Kopec

Lymphatic vessels transport fluid, antigens, and immune cells to the lymph nodes to orchestrate adaptive immunity and maintain peripheral tolerance. Lymphangiogenesis has been associated with inflammation, cancer metastasis, autoimmunity, tolerance and tra ...

Springer2014

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Melody Swartz

Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the tumor microenvironment and in the tumor-draining lymph node. The mechanism unde ...

Amer Assoc Cancer Research2014

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

Melody Swartz

Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma. We first ...

American Society for Clinical Investigation2013

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Melody Swartz, Amanda Waite Lund

Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, ...

Springer Verlag2010

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Melody Swartz, Joseph Rutkowski, Sai Reddy

Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidem ...

American Society for Investigative Pathology2009

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

Melody Swartz, Sandeep Raghunathan, James Brandon Dixon

Lacteals are the entry point of all dietary lipids into the circulation, yet little is known about the active regulation of lipid uptake by these lymphatic vessels, and there lacks in vitro models to study the lacteal-enterocyte interface. We describe an i ...

Wiley-Blackwell2009

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Lymphatic filariasis

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

Molecular and mechanical regulators of lymphatic biology

Graph Chatbot

Chat with Graph Search

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Molecular and mechanical regulators of lymphatic biology

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice