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Related publications (185)
Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness
During the development of mammalian digits, clustered Hoxd genes are expressed following a collinear regulatory strategy, leading to both the growth of digits and their morphological identities. Because gene dosage is a key parameter in this system, we use ...
2008Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome
Several dysmorphic syndromes affect the development of both the eye and the ear, but only a few are restricted to the eye and the external ear. We describe a developmental defect affecting the eye and the external ear in three members of a consanguineous f ...
2008Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd
The extent to which the nuclear organisation of a gene impacts on its ability to be expressed, or whether nuclear organisation merely reflects gene expression states, remains an important but unresolved issue. A model system that has been instrumental in i ...
2008