Concept

Kinesin

Related publications (33)

Mechanisms of procentriole formation

The centrosome comprises a pair of centrioles and associated pericentriolar material, and it is the principal microtubule-organizing centre of most animal cells. Like the genetic material, the centrosome is duplicated once and only once during the cell cyc ...

2008

The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM

Harald Hirling

Correct targeting of proteins to axons and dendrites is crucial for neuronal function. We showed previously that axonal accumulation of the cell adhesion molecule L1/neuron-glia cell adhesion molecule (NgCAM) depends on endocytosis (Wisco, D., E.D. Anderso ...

2008

Processive movement of single kinesins on crowded microtubules visualized using quantum dots

Arne Seitz

Kinesin-1 is a processive molecular motor transporting cargo along microtubules. Inside cells, several motors and microtubule-associated proteins compete for binding to microtubules. Therefore, the question arises how processive movement of kinesin-1 is af ...

Nature Publishing Group2006

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

Henning Paul-Julius Stahlberg, Li Tao, Alex Mogilner

Background: Mitosis depends upon the cooperative action of multiple microtubule (MT)-based motors. Among these, a kinesin-5, KLP61 F, and the kinesin-14, Ncd, are proposed to generate antagonistic-sliding forces that control the spacing of the spindle pole ...

Elsevier BV2006

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans

Henning Paul-Julius Stahlberg

The diversity of sensory cilia on Coenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles, a ...

Rockefeller University Press2006

Exploring the Mechanical Properties of Single Vimentin Intermediate Filaments by Atomic Force Microscopy

László Forró, Andrzej Kulik, Sandor Kasas, Sylvia Jeney, Camilo Guzman

Intermediate filaments (IFs), together with actin filaments and microtubules, compose the cytoskeleton. Among other functions, Ts impart mechanical stability to cells when exposed to mechanical stress and act as a support when the other cytoskeletal filame ...

Elsevier2006

The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent

Pierre Gönczy

gamma-Tubulin-containing complexes are thought to nucleate and anchor centrosomal microtubules (MTs). Surprisingly, a recent study (Strome, S., J. Powers, M. Dunn, K. Reese, C.J. Malone, J. White, G. Seydoux, and W. Saxton. Mol. Biol. Cell. 12:1751-1764) s ...

2002

Nanomechanics of Microtubules

László Forró, Andras Kis, Andrzej Kulik, Sandor Kasas, Willy Benoit

We have determined the mechanical anisotropy of a single microtubule by simultaneously measuring the Young's and the shear moduli in vitro. This was achieved by elastically deforming the microtubule deposited on a substrate tailored by electron-beam lithog ...

American Physical Society2002

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

Pierre Gönczy

Cell divisions that create daughter cells of different sizes are crucial for the generation of cell diversity during animal development. In such asymmetric divisions, the mitotic spindle must be asymmetrically positioned at the end of anaphase. The mechani ...

2001

Purification and analysis of authentic CLIP-170 and recombinant fragments

Françoise Gisou van der Goot Grunberg

We have purified authentic CLIP-170 (cytoplasmic linker protein of 170 kDa) and fragments comprising functional domains of the protein to characterize the structural basis of the function of CLIP-170. Analysis of authentic CLIP-170 and the recombinant frag ...

1999

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