Concept

Glycomics

Related publications (48)

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor

Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylatio ...

American Society for Biochemistry and Molecular Biology2007

Modeling the Isoelectric Focusing of Peptides in an OFFGEL Multicompartment Cell

Hubert Girault, Niels Erik Lion, Hoang-Trang Lam

In proteomic analysis of complex samples at the peptide level (termed shotgun proteomics), an effective prefractionation is crucial to decrease the complexity of the peptide mixture for further analysis. In this perspective, the high-resolving power of the ...

American Chemical Society2007

Glycosylation pathways as drug targets for cancer: glycosidase inhibitors

Sandrine Gerber

The combined and ordered sequential action of glycosidases and glycosyltransferases in mammalian cell compartments leads to the addition of defined glycans to proteins and lipids. Altered glycosylation patterns, neoexpression, underexpression or overexpres ...

2006

Chip electrospray mass spectrometry for carbohydrate analysis

Hubert Girault, Niels Erik Lion

Currently two types of chip systems are used in conjunction with MS: out-of-plane devices, where hundreds of nozzles, nanospray emitters are integrated onto a single silicon substrate from which electrospray is established perpendicular to the substrate, a ...

2005

Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin

David Michael Suter

The glycoprotein IgM is the major antibody produced in the primary immune response to antigens, circulating in the serum both as a pentamer and a hexamer. Pentameric IgM has a single J chain, which is absent in the hexamer. The mu (heavy) chain of IgM has ...

American Society for Biochemistry and Molecular Biology2005

Highly Fluorescent Streptavidin-Coated CdSe Nanoparticles: Preparation in Water, Characterization, and Micropatterning

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Dimitrios Stamou

CdSe quantum dots (QDs) with a high fluorescence quantum yield of 25% and a narrow size distribution were synthesized in a single step in H2O using glutathione as a stabilizing mol. The exceptional optical properties enabled for the 1st time the detection ...

2004

Influence of cell-line and process conditions on the glycosylation of recombinant proteins

The final glycosylation pattern of recombinant proteins might be determined by the choice of the host cell, cell culture conditions and the purification. Each step influences glycosylation and improved glycosylation of the product may thus be obtained by c ...

EPFL2002

Oxidation of 4-chlorophenol at boron-doped diamond electrode for wastewater treatment

Christos Comninellis, Pierre-Alain Michaud, Ilaria Duo, Marco Panizza

The electrochem. behavior of synthetic B-doped diamond thin-film electrode (BDD) was studied in acid media contg. 4-chlorophenol (4-CP) by cyclic voltammetry, chronoamperometry, and bulk electrolysis. The results showed that in the potential region of supp ...

2001

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