Publications related to Point mutation

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Patrick Aebischer, Bernard Schneider, Liliane Glauser, Darren Moore, Klodjan Stafa, Julien Dusonchet

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the pathog ...

Oxford University Press2014

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Anguraj Sadanandam, Shan Jiang

Activating mutations in KRAS are among the most frequent events in diverse human carcinomas and are particularly prominent in human pancreatic ductal adenocarcinoma (PDAC). An inducible Kras(G12D) driven mouse model of PDAC has established a critical role ...

Cell Press2014

Unraveling Patterns of Site-to-Site Synonymous Rates Variation and Associated Gene Properties of Protein Domains and Families

Slavica Dimitrieva Janeva

In protein-coding genes, synonymous mutations are often thought not to affect fitness and therefore are not subject to natural selection. Yet increasingly, cases of non-neutral evolution at certain synonymous sites were reported over the last decade. To ev ...

Public Library of Science2014

On the transition of genetic differentiation from isolation to panmixia: What we can learn from G(ST) and D

Séverine Vuilleumier Varisco

Population genetic differentiation characterizes the repartition of alleles among populations. It is commonly thought that genetic differentiation measures, such as G(ST) and D, should be near zero when allele frequencies are close to their expected value ...

Elsevier2014

On the unfounded enthusiasm for soft selective sweeps

Jeffrey David Jensen

Underlying any understanding of the mode, tempo and relative importance of the adaptive process in the evolution of natural populations is the notion of whether adaptation is mutation limited. Two very different population genetic models have recently been ...

Nature Publishing Group2014

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Bart Deplancke, Andreas Massouras, Sandy Lee, Yi Han, Yiming Zhu

The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We used a ...

Cold Spring Harbor Laboratory Press2014

Periodic versus Intermittent Adaptive Cycles in Quasispecies Coevolution

Alexander Kevin Seeholzer

We study an abstract model for the coevolution between mutating viruses and the adaptive immune system. In sequence space, these two populations are localized around transiently dominant strains. Delocalization or error thresholds exhibit a novel interdepe ...

American Physical Society2014

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Liliane Glauser, Elpida Tsika, Darren Moore, Klodjan Stafa, Amy Jones, Alessandra Musso

Mutations in LRRK2 cause autosomal dominant Parkinsons disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative proteinprotein interaction domains. Familial PD mutations alter the GTPase and kinase activity of L ...

Oxford University Press2014

Shifting Fitness Landscapes In Response To Altered Environments

Jeffrey David Jensen, Claudia Bank

The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 un ...

Wiley-Blackwell2013

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Point mutation

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Unraveling Patterns of Site-to-Site Synonymous Rates Variation and Associated Gene Properties of Protein Domains and Families

On the transition of genetic differentiation from isolation to panmixia: What we can learn from G(ST) and D

On the unfounded enthusiasm for soft selective sweeps

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Periodic versus Intermittent Adaptive Cycles in Quasispecies Coevolution

Structure and properties of the C-terminal beta-helical domain of VgrG protein from Escherichia coli O157

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Shifting Fitness Landscapes In Response To Altered Environments

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Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Shifting Fitness Landscapes In Response To Altered Environments

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

On the unfounded enthusiasm for soft selective sweeps

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Periodic versus Intermittent Adaptive Cycles in Quasispecies Coevolution

Structure and properties of the C-terminal beta-helical domain of VgrG protein from Escherichia coli O157

Unraveling Patterns of Site-to-Site Synonymous Rates Variation and Associated Gene Properties of Protein Domains and Families

On the transition of genetic differentiation from isolation to panmixia: What we can learn from G(ST) and D

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily