Concept
Acylation
Related publications (12)
Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation
Yimon Aye, Pierre Alexander Miranda Herrera
ABSTRACT: Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are under active debate. However, in our opinion, it is becoming increasingly likely that electrophile ...
AMER CHEMICAL SOC2022An Oculus to Profile and Probe Target Engagement In Vivo: How T-REX Was Born and Its Evolution into G-REX
Here we provide a personal account of innovation and design principles underpinning a method to interrogate precision electrophile signaling that has come to be known as "REX technologies". This Account is framed in the context of trying to improve methods ...
AMER CHEMICAL SOC2021Where Electrophile Signaling and Covalent Ligand-Target Mining Converge
Interests in learning how to engineer most effective covalent ligands, identify novel functional targets, and define precise mechanism-of-action are rapidly growing in both academia and pharmaceutical industries. We here illuminate the establishment of a m ...
SWISS CHEMICAL SOC2020Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Mohamed Adbelalim Gadalla
Hemagglutinin (HA), a glycoprotein of Influenza A viruses and its proton channel M2 are site-specifically modified with fatty acids. Whereas two cysteines in the short cytoplasmic tail of HA contain only palmitate, stearate is exclusively attached to one c ...
PORTLAND PRESS LTD2020Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals
With a lipid-rich environment and elevated oxygen consumption, the central nervous system (CNS) is subject to intricate regulation by lipid-derived electrophiles (LDEs). Investigations into oxidative damage and chronic LDE generation in neural disorders ha ...
FRONTIERS MEDIA SA2020Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation
Nicolai Cramer, Laetitia Marie Mélanie Souillart
The lactone motif is ubiquitous in natural products and pharmaceuticals. The Tishchenko disproportionation of two aldehydes, a carbonyl hydroacylation, is an efficient and atom-economic access to lactones. However, these reaction types are limited to the t ...
Wiley-Blackwell2014Synthesis of C-linked Disaccharides and Analogues as Biomimetics of the TF Epitope
Glycoproteins and glycolipids are major components of the outer surface of mammalian cells. Their carbohydrate moieties, which are directed into the outer environment, serve as ligands for receptor proteins, such as lectins, pathogen proteins and antibodie ...
EPFL2011