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Many different forms of synaptic plasticity have been shown to ultimately modulate the number of AMPA-type glutamate receptors at the synapse. This trafficking involves lateral movements between synaptic and extrasynaptic sites at the neuron surface, as we ...
Given the complex structure of the brain, how can synaptic plasticity explain the learning and forgetting of associations when these are continuously changing? We address this question by studying different reinforcement learning rules in a multilayer netw ...
Changes of synaptic connections between neurons are thought to be the physiological basis of learning. These changes can be gated by neuromodulators that encode the presence of reward. We study a family of reward-modulated synaptic learning rules for spiki ...
The aim of this study is to contribute to understand the physiology of the Olfactory System through detailed microcircuit investigation, adopting advanced electrophysiological and anatomical techniques. Multiple patch clamp recordings allow understanding t ...
In computational neuroscience, it is of crucial importance to dispose of a model that is able to accurately describe the single-neuron activity. This model should be at the same time biologically relevant and computationally fast. Many different phenomenol ...
Inter-pyramidal synaptic connections are characterized by a wide range of EPSP amplitudes. Although repeatedly observed at different brain regions and across layers, little is known about the synaptic characteristics that contribute to this wide range. In ...
Reinforcement learning in neural networks requires a mechanism for exploring new network states in response to a single, nonspecific reward signal. Existing models have introduced synaptic or neuronal noise to drive this exploration. However, those types o ...
Synaptic plasticity is considered to be the biological substrate of learning and memory. In this document we review phenomenological models of short-term and long-term synaptic plasticity, in particular spike-timing dependent plasticity (STDP). The aim of ...
Despite the impressive progress of logic synthesis in the past decade, finding the best architecture for a given circuit still remains an open and largely unsolved problem, especially for arithmetic circuits. In many cases, the outcome of even the most adv ...
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A core feature of autism spectrum disorders is the impairment in social interactions. Among other brain regions, a deficit in amygdala processing has been suggested to underlie this impairment, but whether the amygdala is processing fear abnormally in auti ...