Publications related to Ototoxicity

AAV based gene therapy for rare diseases

Of the seven thousand diseases that are described as rare, 80% of them have an identified genetic cause. With this in the mind, the development of technologies, such as gene therapy, to address the genetic factors involved in these pathologies, might be a ...

EPFL2017

Up-Down Chair: A novel mechatronic device to assess otolith function in patients with vestibular disorders

Silvestro Micera

This paper describes a novel mechatronic platform, named "Up-Down Chair" (UDC), aimed at investigating otolith function in patients with vestibular disorders. The UDC was designed to provide a wide range of repeatable and controllable vertical oscillations ...

Elsevier Sci Ltd2016

Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation

Silvestro Micera, Thuy Anh Khoa Nguyen, Maurizio Ranieri

Objective. The vestibular system provides essential information about balance and spatial orientation via the brain to other sensory and motor systems. Bilateral vestibular loss significantly reduces quality of life, but vestibular implants (VIs) have demo ...

Iop Publishing Ltd2016

Dissipation engineering of high-stress silicon nitride nanobeams

Tobias Kippenberg, Dalziel Joseph Wilson, Amir Hossein Ghadimi

High-stress Si

_3

N

_4

nanoresonators have become an attractive choice for electro- and optomechanical devices. Membrane resonators can achieve quality factor (

Q

) - frequency (

f

) products exceeding

10^{13}

Hz, enabling (in principle) quantum coheren ...

2016

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

Paul Joseph Dyson, Alexey Nazarov

New ruthenium and osmium carbonyl clusters with 1,3,5-triaza-7-phosphatricyclo-[3.3.1.13.7]decane and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane ligands were synthesized using Me3NO as an initiator. The data on antiproliferative activity of ne ...

Springer Verlag2016

Novel Chemosensors for Biologically Important Analytes

Ziya Köstereli

In this work, fluorescent-based chemosensors for the detection of important analytes in aqueous solution are described. The sensors are based on different detection concepts, including analyte-induced aggregation/de-aggregation, pattern-based sensing and m ...

EPFL2015

Detection of hyperacusis condition in tinnitus patients based on PLSC features that link audiogram and fMRI tonotopy responses

Dimitri Nestor Alice Van De Ville, Melissa Saenz, Wietske Van der Zwaag, Naghmeh Ghazaleh

Tinnitus is the chronic perception of ringing or other phantom sounds. Some tinnitus patients addi- tionally suffer from loudness hyperacusis that is the over-sensitivity to environmental sounds. Here, we recruited eight patients with unilateral hearing lo ...

2015

Balancing the Self

Mariia Kaliuzhna

The vestibular system is composed of otolith organs and semi-circular canals that encode linear and angular accelerations, as well as the position of the head with respect to gravity. Thus, the detection of self-motion, the distinction between self- and ob ...

EPFL2015

Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct

Friedrich Beermann

The extracellular potential of excitable and nonexcitable cells with respect to ground is ∼0 mV. One of the known exceptions in mammals is the cochlear duct, where the potential is ∼80-100 mV, called the endocochlear potential (EP). The EP serves as the "b ...

Society for Neuroscience2013

Two-photon microscopy of the mouse cochlea in situ for cellular diagnosis

Demetri Psaltis, Ye Pu, Chia-Lung Hsieh, Xin Yang

Sensorineural hearing loss is the most common type of hearing loss worldwide, yet the underlying cause is typically unknown because the inner ear cannot be biopsied today without destroying hearing, and intracochlear cells have not been imaged with resolut ...

Spie-Soc Photo-Optical Instrumentation Engineers2013

Ototoxicity

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AAV based gene therapy for rare diseases

Up-Down Chair: A novel mechatronic device to assess otolith function in patients with vestibular disorders

Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation

Dissipation engineering of high-stress silicon nitride nanobeams

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

Novel Chemosensors for Biologically Important Analytes

Detection of hyperacusis condition in tinnitus patients based on PLSC features that link audiogram and fMRI tonotopy responses

Balancing the Self

Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct

Two-photon microscopy of the mouse cochlea in situ for cellular diagnosis

AAV based gene therapy for rare diseases

Dissipation engineering of high-stress silicon nitride nanobeams

Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation

Up-Down Chair: A novel mechatronic device to assess otolith function in patients with vestibular disorders

Novel Chemosensors for Biologically Important Analytes

Two-photon microscopy of the mouse cochlea in situ for cellular diagnosis

Balancing the Self

Detection of hyperacusis condition in tinnitus patients based on PLSC features that link audiogram and fMRI tonotopy responses

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct