Concept

Pre-replication complex

Related publications (37)

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

Bacteria are ubiquitous single cellular organisms. Compared to eukaryotic cells, bacteria have two unique characteristics: the membrane-less nucleoid and the cell wall built of peptidoglycan (PG). In most bacteria, a single circular chromosome is compacted ...

EPFL2024

Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutS gamma complex

Alexander Woglar

Crossover formation is essential for proper segregation of homologous chromosomes during meiosis. Here, we show that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) partners with cyclin-like protein COSA-1 to promote crossover formation by promoti ...

NATL ACAD SCIENCES2022

Coordination between cell growth, division and chromosome replication cycles in mycobacteria

Gaëlle Madeleine Vuaridel

Propagation of microorganisms is based on three fundamental processes: cell growth, DNA replication, and cell division. Although important for antibacterial drug development, these processes are poorly understood in Actinobacteria, a medically important ph ...

EPFL2021

PaRiS: Causally Consistent Transactions with Non-blocking Reads and Partial Replication

Willy Zwaenepoel, Diego Didona, Kristina Spirovska

Geo-replicated data platforms are at the backbone of several large-scale online services. Transactional Causal Consistency (TCC) is an attractive consistency level for building such platforms. TCC avoids many anomalies of eventual consistency, eschews the ...

2019

PaRiS: Causally Consistent Transactions with Non-blocking Reads and Partial Replication

Willy Zwaenepoel, Diego Didona, Kristina Spirovska

Geo-replicated data platforms are the backbone of several large-scale online services. Transactional Causal Consistency (TCC) is an attractive consistency level for building such platforms. TCC avoids many anomalies of eventual consistency, eschews the syn ...

IEEE COMPUTER SOC2019

Analysis of the S. pombe Meiotic Proteome Reveals a Switch from Anabolic to Catabolic Processes and Extensive Post-transcriptional Regulation

Viesturs Simanis, Romain Hamelin, Andrea Krapp, Florence Armand, Diego Chiappe, Lucien Fabrice Krapp, Marc Moniatte, Elena Cano

Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the rela ...

2019

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Patricia Renck Nunes

Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveilla ...

Springer2019

An essential thioredoxin is involved in the control of the cell cycle in the bacterium Caulobacter crescentus

Camille Véronique Bernadette Goemans

Thioredoxins (Trxs) are antioxidant proteins that are conserved among all species. These proteins have been extensively studied and perform reducing reactions on a broad range of substrates. Here, we identified Caulobacter crescentus Trx1 (CCNA_03653; CcTr ...

2018

Wren: Nonblocking Reads in a Partitioned Transactional Causally Consistent Data Store

Willy Zwaenepoel, Diego Didona, Kristina Spirovska

Transactional Causal Consistency (TCC) extends causal consistency, the strongest consistency model compatible with availability, with interactive read-write transactions, and is therefore particularly appealing for geo-replicated platforms. This paper pres ...

2018

Chromosome Organization and Replisome Dynamics in Mycobacterium smegmatis

John McKinney, Isabella Santi

Subcellular organization of the bacterial nucleoid and spatiotemporal dynamics of DNA replication and segregation have been studied intensively, but the functional link between these processes remains poorly understood. Here we use quantitative time-lapse ...

American Society for Microbiology2015

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