Concept

Aciclovir

Related publications (13)

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles

JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population. In rare cases of severe immune suppression, the virus is able to establish a lytic infectio ...

Washington2023

High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections

Gerardo Turcatti, Fabien Kuttler

Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- ...

2022

Modified cyclodextrins as broad-spectrum antivirals

Francesco Stellacci, Natalia Gasilova, Matteo Gasbarri, Valeria Cagno, Samuel Thomas Jones, Matej Janecek

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed n ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Host miRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency

Jiri Vanicek

Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular miRNAs in ce ...

American Society for Microbiology2014

Simplex-Coded BOTDA Sensor Over 120-km SMF With 1-m Spatial Resolution Assisted by Optimized Bidirectional Raman Amplification

Marcelo Alfonso Soto Hernandez

Bidirectional low-noise Raman amplification and simplex coding based on the return-to-zero modulation format are optimized through numerical simulations for long-range Brillouin optical time-domain analysis sensing. Experimental results are reported on sen ...

2012

Optimization of a DPP-BOTDA sensor with 25 cm spatial resolution over 60 km standard single-mode fiber using Simplex codes and optical pre-amplification

Marcelo Alfonso Soto Hernandez

Sub-meter distributed optical fiber sensing based on Brillouin optical time-domain analysis with differential pulse-width pairs (DPP-BOTDA) is combined with the use of optical pre-amplification and pulse coding. In order to provide significant measurement ...

Optical Society of America2012

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

Didier Trono

HIV infection can persist in spite of efficacious antiretroviral therapies. Although incomplete inhibition of viral replication may contribute to this phenomenon, this is largely due to the early establishment of a stable reservoir of latently infected cel ...

American Association for the Advancement of Science2010

Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping

Didier Trono

The HIV-1 regulatory proteins Tat and Rev are encoded by multiply spliced mRNAs that differ by the use of alternative 3' splice sites at the beginning of the internal exon. If these internal exons are skipped, the expression of these genes, and hence HIV-1 ...

Wiley-Blackwell2007

Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression

Patrick Aebischer, Bernard Schneider

BACKGROUND: Encapsulating cells prevents the immune destruction of allogeneic cells in the subcutaneous site as well as allogeneic and xenogeneic cells in the central nervous system. However, when encapsulated xenogeneic cells are implanted s.c., they may ...

2000

Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes

Didier Trono

We exploited the ability of lentiviral vectors to govern the stable transduction of cells irrespective of their cycling status to induce the reversible immortalization of human primary cells. First, bicistronic HIV-derived lentiviral vectors expressing GFP ...

2000

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