Concept

Autophagy

Related publications (60)

Intrinsic GTPase activity of a bacterial twin-arginine translocation proofreading chaperone induced by domain swapping

The bacterial twin-arginine translocation (Tat) system is a protein targeting pathway dedicated to the transport of folded proteins across the cytoplasmic membrane. Proteins transported on the Tat pathway are synthesised as precursors with N-terminal signa ...

2010

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Mirko Bischofberger, Romain Fernand Pietro Groux

The anthrax toxin is a tripartite toxin, where the two enzymatic subunits require the third subunit, the protective antigen (PA), to interact with cells and be escorted to their cytoplasmic targets. PA binds to cells via one of two receptors, TEM8 and CMG2 ...

Public Library of Science2010

Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy

Françoise Gisou van der Goot Grunberg, Nicolas Dupont

Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected ...

2009

The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells

Jordi Duran

The regulation of autophagy in metazoans is only partly understood, and there is a need to identify the proteins that control this process. The diabetes- and obesity-regulated gene (DOR), a recently reported nuclear cofactor of thyroid hormone receptors, i ...

2009

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

Hilal Lashuel

In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recess ...

Public Library of Science2009

Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally

Philipp Bucher, Jutta Christine Wandrey

Introduction. One of the major barriers affecting the viability of encapsulated islets is pericapsular ﬁbrotic inﬁltration (PFI). This study aimed to design strategies to reduce PFI around intraportally injected alginate microbeads. Methods. Empty, highly ...

2004

Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes

Françoise Gisou van der Goot Grunberg

Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the attenuated strain 19 (S19) in HeLa cells. ...

1998

Telomerase and chromosome end maintenance

Joachim Lingner

The past year has seen significant advances in our understanding of telomerase and other factors involved in chromosome end maintenance. The protein subunit of telomerase that provides the active site for telomeric DNA synthesis was identified in ciliates, ...

1998

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

Michel Aguet

The JAK-STAT signaling pathway has been implicated in mediating biological responses induced by many cytokines. However, cytokines that promote distinct cellular responses often activate identical STAT proteins, thereby raising the question of how specific ...

1996

Coordination of cellular iron metabolism by post-transcriptional gene regulation

Lukas Kühn

Maintenance of cellular iron homeostasis demands the coordination of iron uptake, intracellular storage, and utilization. Recent investigations suggest that a single genetic regulatory system orchestrates the expression of proteins with central importance ...

1992

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