Concept

Pyramidal cell

Related publications (195)

Predicting spike timing of neocortical pyramidal neurons by simple threshold models

Neurons generate spikes reliably with millisecond precision if driven by a fluctuating current—is it then possible to predict the spike timing knowing the input? We determined parameters of an adapting threshold model using data recorded in vitro from 24 l ...

2006

Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: a three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana

Chronic stress and spatial training have been proposed to affect hippocampal structure and function in opposite ways. Previous morphological studies that addressed structural changes after chronic restraint stress and spatial training were based on two-dim ...

2005

Short-term-plasticity orchestrates the response of pyramidal cells and interneurons to population bursts

Wulfram Gerstner, Henry Markram, Gilad Silberberg

The synaptic drive from neuronal populations varies considerably over short time scales. Such changes in the presynaptic rate trigger many temporal processes absent under steady-state conditions. This paper examines the differential impact of pyramidal cel ...

2005

Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking

Pierre Magistretti, Luc Pellerin

MCT2 is the main neuronal monocarboxylate transporter needed by neurons if they are to use lactate as an additional energy substrate. Previous evidence suggested that some MCT2 could be located in postsynaptic elements of glutamatergic synapses. Using post ...

2005

Effective minimal threshold models of neuronal activity

Renaud Jolivet

This work investigates the capacity of Integrate-and-Fire-type (I&F-type) models to quantitatively predict spike trains of real neurons in various laboratory and in vivo-like settings. A step-by-step methodology is developed to build an equivalent effectiv ...

EPFL2005

The neocortical microcircuit as a tabula rasa

Henry Markram, Gilad Silberberg

The neocortex has a high capacity for plasticity. To understand the full scope of this capacity, it is essential to know how neurons choose particular partners to form synaptic connections. By using multineuron whole-cell recordings and confocal microscopy ...

2005

Adaptive Exponential Integrate-and-Fire Model as an Effective Description of Neuronal Activity

Wulfram Gerstner, Romain Brette

We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiologi ...

American Physiological Society2005

Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat

Henry Markram, Gilad Silberberg, Yi Wang

Whole-cell patch-clamp recordings followed by histochemical staining and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical ...

2004

Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation

Pierre Magistretti, Luc Pellerin

Regulation of the expression of MCT1 and MCT2, two isoforms of the monocarboxylate transporter (MCT) family, was investigated in primary cultures of mouse cortical neurons. Under basal conditions, both MCT immunoreactivities (IR) were found in the cell som ...

2003

Spatiotemporal dynamics of sensory responses in layer 2/3 of rat barrel cortex measured in vivo by voltage-sensitive dye imaging combined with whole-cell voltage recordings and neuron reconstructions

Carl Petersen

The spatiotemporal dynamics of the sensory response in layer 2/3 of primary somatosensory cortex evoked by a single brief whisker deflection was investigated by simultaneous voltage-sensitive dye (VSD) imaging and whole-cell (WC) voltage recordings in the ...

2003

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