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Reelin

Related publications (68)

Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease

Despite decades of research in Alzheimerâs disease (AD), no treatment has been found to efficiently prevent or cure its progression. The microtubule binding protein Tau plays central roles in the pathogenesis of AD and is found, in the form of paired hel ...

EPFL2017

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies

László Forró, Hilal Lashuel, Endre Horvath, Anne-Laure Mahul Mellier, Massimo Spina, Bohumil Maco, Ryma Iness Benmessaoud

New technologies launch novel materials; besides their performances in products, their health hazards must be tested. This applies to the lead halide perovskite CH3NH3PbI3 as well, which offers fulgurate applications in photovoltaic devices. We report the ...

Royal Soc Chemistry2016

Once generated, neurons are thought to permanently exit the cell cycle and become irreversibly differentiated. However, neither the precise point at which this post-mitotic state is attained nor the extent of its irreversibility is clearly defined. Here we ...

Inst Biochemistry & Cell Biology2016

What lies beneath? Diffusion EAP-based study of brain tissue microstructure

Alessandro Daducci, Cristina Granziera, Gloria Menegaz

Diffusion weighted magnetic resonance signals convey information about tissue microstructure and cytoarchitecture. In the last years, many models have been proposed for recovering the diffusion signal and extracting information to constitute new families o ...

Elsevier Science Bv2016

Emerging as an important correlate of neurological dysfunction in Multiple Sclerosis (MS), extended focal and diffuse gray matter abnormalities have been found and linked to clinical manifestations such as seizures, fatigue and cognitive dysfunction. To in ...

Elsevier2015

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and gamma-secretase

Patrick Fraering, Sébastien Mosser, Eugenio Barone

Rapid remodeling of the actin cytoskeleton in the pre- and/or post-synaptic compartments is responsible for the regulation of neuronal plasticity, which is an important process for learning and memory. Cofilin1 plays an essential role in these processes an ...

Elsevier Science Bv2014

A Hierarchical Structure of Cortical Interneuron Electrical Diversity Revealed by Automated Statistical Analysis

Henry Markram, Sean Lewis Hill, Idan Segev

Although the diversity of cortical interneuron electrical properties is well recognized, the number of distinct electrical types (e-types) is still a matter of debate. Recently, descriptions of interneuron variability were standardized by multiple laborato ...

Oxford University Press2013

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Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation is associated with neurofibrillary tangle formation in humans, and the ...

Elsevier Science Inc2013

Cognitive disorganisation and Sex affect visual backward masking: data from patients with schizophrenia, non-affected relatives and healthy controls

Michael Herzog, Christine Mohr, Maya Roinishvili, Guillaume Sierro

Endophenotypes (i.e. stable and heritable markers of the illness) are one of the promising tools to understand the pathological mechanisms underlying schizophrenia. We recently showed that deficits in visual backward masking (VBM) meet the criteria for an ...

2013

Lithium rescues synaptic plasticity and memory in Down syndrome mice

Diego Ghezzi

Down syndrome (DS) patients exhibit abnormalities of hippocampal-dependent explicit memory, a feature that is replicated in relevant mouse models of the disease. Adult hippocampal neurogenesis, which is impaired in DS and other neuropsychiatric diseases, p ...

American Society for Clinical Investigation2013

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