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Related publications (68)

Cellular mechanisms regulating adult neurogenesis and olfactory perception in mice

Maria del Carmen Sandi Perez, Thomas Brionne

In the adult mammalian brain, neural stem cells persist in the subventricular zone and the hippocampus, producing new functional neurons throughout life. Whether and how adult neurogenesis maintains brain function remains highly debated. This question is o ...

EPFL2007

Facilitating sensory responses in developing mouse somatosensory barrel cortex

Carl Petersen, James Poulet

The sensory responses in the barrel cortex of mice aged postnatal day (P)7-P12 evoked by a single whisker deflection are smaller in amplitude and spread over a smaller area than those measured in P13-P21 mice. However, repetitive 10-Hz stimulation or paire ...

2007

Effective minimal threshold models of neuronal activity

Renaud Jolivet

This work investigates the capacity of Integrate-and-Fire-type (I&F-type) models to quantitatively predict spike trains of real neurons in various laboratory and in vivo-like settings. A step-by-step methodology is developed to build an equivalent effectiv ...

EPFL2005

Validation of glutathione quantitation from STEAM spectra against edited 1H NMR spectroscopy at 4T: Application to schizophrenia

Rolf Gruetter

Objective: Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinic ...

2005

Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat

Henry Markram, Gilad Silberberg, Yi Wang

Whole-cell patch-clamp recordings followed by histochemical staining and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical ...

2004

Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors

Freddy Radtke

The Notch and fibroblast growth factor (FGF) pathways both regulate cell fate specification during mammalian neural development. We have shown previously that Notch1 activation in the murine forebrain promotes radial glial identity. This result, together w ...

2004

Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin

Evidence suggests that lactate could be a preferential energy substrate transferred from astrocytes to neurons. Such a process implies the presence of specific monocarboxylate transporters on both cell types. Expression of MCT1 and MCT2, two isoforms of th ...

2003

A three-dimensional multi-electrode array for multi-site stimulation and recording in acute brain slices

Philippe Renaud, Marc Olivier Heuschkel

Several multi-electrode array devices integrating planar metal electrodes were designed in the past 30 years for extracellular stimulation and recording from cultured neuronal cells and organotypic brain slices. However, these devices are not well suited f ...

2002

Opposite regulation of calbindin and calretinin expression by brain-derived neurotrophic factor in cortical neurons

Pierre Magistretti, Jean-Luc Martin

Regulation of calbindin and calretinin expression by brain-derived neurotrophic factor (BDNF) was examined in primary cultures of cortical neurons using immunocytochemistry and northern blot analysis. Here we report that regulation of calretinin expression ...

2000

Differential effect of thyroid hormone deficiency on the growth of calretinin-expressing neurons in rat spinal cord and dorsal root ganglia

Pierre Magistretti, Thibault Adrien Kuntzer

The development of spinal cord or dorsal root ganglia neurons expressing calretinin (CR) was studied in thyroid hormone-deficient rats. Immunocytochemical and morphometric analyses showed that the hypothyroidism induced a significant decrease in the number ...

2000

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