Concept

Crohn's disease

Related publications (49)

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...

AMER PHYSIOLOGICAL SOC2019

Identification and characterisation of small-molecule inhibitors targeting STING

Simone Margret Haag

The recognition of pathogen-derived nucleic acids is a critical mechanism by which the innate immune system detects viral infection. Upon activation, nucleic acid sensors initiate the expression of type I interferons and other inflammatory mediators, subse ...

EPFL2019

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Johan Auwerx, Evan Graehl Williams

The BXD family has become one of the preeminent genetic reference populations to understand the genetic and environmental control of phenotypic variation. Here we evaluate the responses to different levels of fat in the diet using both chow diet (CD, 13-18 ...

PUBLIC LIBRARY SCIENCE2019

Short term exposure to fine particulate matter and hospital admission risks and costs in the Medicare population: time stratified, case crossover study

Yun Wang, Christine Choirat

OBJECTIVE To assess risks and costs of hospital admission associated with short term exposure to fine particulate matter with diameter less than 2.5 mu m (PM2.5) for 214 mutually exclusive disease groups. DESIGN Time stratified, case crossover analyses wit ...

BMJ2019

Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

Ulrich Hoffmann

CD44 is a transmembrane molecule appearing in numerous isoforms generated by insertions of alternatively spliced variant exons (CD44v) and having various binding partners. CD44v7 on T cells was proposed to promote colitis by preventing T-cell apoptosis. He ...

NATURE PUBLISHING GROUP2018

Oral application of Escherichia coli bacteriophage: safety tests in healthy and diarrheal children from Bangladesh

Patrick Descombes

A T4-like coliphage cocktail was given with different oral doses to healthy Bangladeshi children in a placebo-controlled randomized phase I safety trial. Fecal phage detection was oral dose dependent suggesting passive gut transit of coliphages through the ...

Wiley-Blackwell2017

Intimate gut interactions: helminths and the microbiota

Nicola Harris

Changing exposure to intestinal helminths, or alterations in our intestinal microbiome, have been independently proposed to underlie the increasing incidence of chronic inflammatory diseases including allergy, autoimmunity and inflammatory bowel disease (I ...

Inst Biochemistry & Cell Biology2016

miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation

Michele De Palma, Mario Leonardo Squadrito

MiR-511-3p is embedded in intron 5 of the CD206/MRC1 gene Mrc1, expressed by macrophage and dendritic cell populations. CD206 and miR-511-3p expression are co-regulated, and their contribution to intestinal inflammation is unclear. We investigated their ro ...

Nature Publishing Group2016

The consensus molecular subtypes of colorectal cancer

Douglas Hanahan, Krisztian Homicsko, Sarah Gerster, Paolo Angelino, Mauro Delorenzi, Anguraj Sadanandam, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Alessandra Piersigilli, Adrienne Joëlle Laurence Mottis, Keir Joe Menzies, Hiroyasu Yamamoto, Giuseppe Lo Sasso

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

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