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The excitatory amino acid glutamate was previously shown to stimulate aerobic glycolysis in astrocytes by a mechanism involving its uptake through an Na+-dependent transporter. Evidence had been provided that Na+,K+-ATPase might be involved in this process ...
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of the pathway's rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). The nuclear receptor LXRalpha binds oxysterols and ...
Epoxidation of (1RS,2SR,3SR,4RS,6RS,7RS,8RS, 12RS, 13RS)-6,13-bis(benzyloxy)-15,16-dioxapentacyclo[10. 2.1.1(4.7).0(2,11).0(3.8)]hexadec-10-en-8-yl-methanol (12) led to the stereoselective formation of (1RS,2RS,3RS,5RS,6SR, 7RS,8RS, 10RS,11SR, 12SR,16SR)-3 ...
Cholesterol and bile acid metabolism is tightly controlled by nuclear receptors. The liver X receptor, an oxysterol-activated nuclear receptor, limits cholesterol accumulation in the body both by stimulating reverse cholesterol transport and by inhibiting ...
After administration of enriched [1-13C]glucose, the rate of 13C label incorporation into glutamate C4, C3, and C2, glutamine C4, C3, and C2, and aspartate C2 and C3 was simultaneously measured in six normal subjects by 13C NMR at 4 Tesla in 45-ml volumes ...
A new concept for the construction of macrocyclodepsipeptides from simple and readily available starting materials has been developed. The sequence consists of (a) a three-component reaction of an aldehyde, an amino alc., and a dipeptide isocyanate and (b) ...
The natural beta-amino acid deriv. Boc-Asp-OBn (Boc = Me3CO2C; Bn = CH2Ph), as well as I (R = CH2CH2CO2Bn, CH2OBn; TCE = CH2CCl3) (prepd. from appropriately protected glutamic acid and serine, resp., by Arndt-Eistert homologation), were employed as buildin ...
Cyclo-beta-tetrapeptide I, a beta-peptidic analog of octreotide, was prepd. from beta-amino acid building blocks synthesized by Arndt-Eistert homologation of appropriately protected alpha-amino acids. The affinity of I for five different human somatostatin ...
Resolved localized nuclear magnetic resonance (NMR) signals of 1H bound to 13C label in the carbon positions of glutamate C4, C3 and glutamine C4, C3, as well as in aspartate C3, lactate C3, alanine C3, γ,-aminobutyric acid C3, and glucose C1 were simultan ...
A quant. structure-reactivity relationship for the Michael-type addn. of thiols onto acrylates was detd. Several thiol-contg. peptides were investigated by examg. the correlation between the second-order rate const. of their addn. onto PEG-diacrylate and t ...
