Concept
Kidney disease
Related publications (46)
Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation
Antonia Neels, Marianne Liebi, Tiberiu Totu
Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a ple ...
Elsevier2024Roles of Clinical Features and Chest CT in Predicting the Outcomes of Hospitalized Patients with COVID-19 Developing AKI
Ali Falsafi, Shekoofeh Yaghmaei
This research aimed to evaluate the clinical features and computed tomography (CT) scans associated with poor outcomes in COVID-19 patients with acute kidney injury (AKI). A total of 351 COVID-19 patients (100 AKI, 251 non-AKI) hospitalized at Imam Hossein ...
IRANIAN SOC NEPHROLGY2023NAD(+) Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease
Premature aging causes morphological and functional changes in the kidney, leading to chronic kidney disease (CKD). CKD is a global public health issue with far-reaching consequences, including cardio-vascular complications, increased frailty, shortened li ...
MDPI2023New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys.
Bicaudal-C1 (Bicc1), an RNA-Binding protein, is a ciliopathy-associated protein. In development, Bicc1 is necessary for left-right axis specification. Loss of Bicc1 in mice also associates with polycystic kidney development. In human, two hereditary polycy ...
EPFL2023Causal inference with recurrent and competing events
Mats Julius Stensrud, Pal Christie Ryalen, Matias Janvin
Many research questions concern treatment effects on outcomes that can recur several times in the same individual. For example, medical researchers are interested in treatment effects on hospitalizations in heart failure patients and sports injuries in ath ...
SPRINGER2023Assessment of Stiffness of Large to Small Arteries in Multistage Renal Disease Model: A Numerical Study
Nikolaos Stergiopoulos, Vasiliki Bikia, Patrick Segers
Arterial stiffness (AS), as assessed via pulse wave velocity (PWV), is a major biomarker for cardiovascular risk assessment in patients with chronic kidney disease (CKD). However, the mechanisms responsible for the changes in PWV in the presence of kidney ...
FRONTIERS MEDIA SA2022Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis
Arnaud Comment, Hikari Ananda Infinity Yoshihara
As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to be measured more routinely. ...
2021Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease
Johan Auwerx, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Joseph Rutkowski, Renuga Devi Rajaram
Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...
2021Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores
Jacques Fellay, Christian Axel Wandall Thorball
Background In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m(2) per year for >= 3 ...
OXFORD UNIV PRESS INC2021Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice
Dmitri Firsov, Hikari Ananda Infinity Yoshihara, Jean-Luc Barras, Nicolas Dattner
Aim Arginase 2 (ARG2) is a mitochondrial enzyme that catalyses hydrolysis ofl-arginine into urea andl-ornithine. In the kidney, ARG2 is localized to the S3 segment of the proximal tubule. It has been shown that expression and activity of this enzyme are up ...
WILEY2020